Prevalence of metabolic dysfunction-associated steatotic liver disease and steatohepatitis in Türkiye: A forensic autopsy study

被引:2
|
作者
Ergenc, Ilkay [1 ,2 ]
Kara, Erdogan [3 ]
Yilmaz, Muhammed Emre [3 ]
Demirtas, Coskun Ozer [1 ]
Keklikkiran, Caglayan [4 ]
Das, Taner [3 ]
Buyuk, Yalcin [3 ,5 ]
Celikel, Cigdem [6 ]
Asliyuksek, Hizir [3 ]
Yilmaz, Yusuf [1 ,4 ]
机构
[1] Marmara Univ, Sch Med, Dept Gastroenterol, Istanbul, Turkiye
[2] Kings Coll Hosp London, Inst Liver Studies, London, England
[3] Minist Justice, Council Forens Med, Istanbul, Turkiye
[4] Recep Tayyip Erdogan Univ, Sch Med, Dept Gastroenterol, Rize, Turkiye
[5] Istanbul Univ Cerrahpasa, Inst Legal Med & Forens Sci, Istanbul, Turkiye
[6] Marmara Univ, Sch Med, Dept Pathol, Istanbul, Turkiye
关键词
MASLD; Steatohepatitis; Liver; Steatosis; Autopsy; Histology; FATTY LIVER; ULTRASONOGRAPHY; TURKEY; RISK;
D O I
10.1016/j.heliyon.2024.e34915
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global epidemic in T & uuml;rkiye and worldwide. The aim of this study was to evaluate the prevalence and predictors of MASLD and steatohepatitis among adults who died of unnatural causes including sudden death and non-burn trauma. Method: We conducted a prospective review of all consecutive adult forensic autopsies for natural (sudden unexpected) and non-natural (Suicidal, homicidal and accidental) suspicious deaths carried out at the Istanbul Council of Forensic Medicine from February to May 2022. Four wedge biopsies were extracted from sagittal sectioned liver specimens. A liver pathologist with 20 years of experience examined each case for steatosis, ballooning, inflammation, and fibrosis. Results: Among 1797 autopsies, 62 met inclusion criteria. Overall, 43.3 % (n = 26) of autopsies showed evidence of steatotic liver disease, with a distribution of steatosis severity as: Grade I (28.3 %), Grade II (6.6 %), and Grade III (8.3 %). All these cases met at least one cardiometabolic criteria and diagnosed with MASLD. Ballooning was observed in 20.0 % of cases (5 cases grades 1 and 7 cases grade 2), and Inflammation was present in 51.7 % (9 cases with grade 0-1, 12 with 1-2, 7 with 2-3, and 3 with 5-6). Notably, 46.1 % (n = 12) of MASLD cases and 20.0 % (n = 12) of all cases were diagnosed with steatohepatitis, with three cases exhibiting delicate perisinusoidal fibrosis and one case showing portal fibrosis. Conclusion: The histopathological findings from this autopsy study confirmed the markedly high prevalence of MASLD and steatohepatitis within the general adult population, highlighting the concerning burden of steatotic liver disease in T & uuml;rkiye.
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页数:7
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