Metal free C-O bond cleavage: a new strategy for the synthesis of substituted oxazoles

被引：1

作者：

Li, Shengwang ^{[1
]}

Liu, Guiqin ^{[1
]}

Zhang, Zheyan ^{[1
]}

Chen, Ruiling ^{[2
]}

Tian, Haiying ^{[2
]}

Wang, Huifeng ^{[1
]}

Chen, Xiuling ^{[1
]}

机构：

[1] Hubei Univ Sci & Technol, Hubei Key Lab Radiat Chem & Funct Mat, Xianning 437100, Peoples R China

[2] Changzhi Med Coll, Sch Pharm, Changzhi 046000, Peoples R China

来源：

RSC ADVANCES | 2024年 / 14卷 / 38期

基金：

中国国家自然科学基金;

关键词：

CROSS-COUPLING REACTIONS; ONE-POT SYNTHESIS; ETHERS; OXYGENATION; CYCLIZATION; ACTIVATION; KETONES; AZOLES; ESTERS; CARBON;

D O I：

10.1039/d4ra05122j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strategy for the efficient metal-free C-O bond cleavage of ester using amines for the synthesis of substituted oxazoles was developed for the first time. The synthesis proceeded smoothly under metal-free conditions, combining C-O bond cleavage as well as C-N and C-O bond formation in one pot to yield desired products in moderate to excellent yields, and accommodated a wide range of functional groups and substrates. A strategy for C-O bond cleavage of ester for the synthesis of substituted oxazoles was developed. The synthesis proceeded smoothly under metal-free conditions, combining C-O bond cleavage, C-N and C-O bond formation in one pot.

引用

页码：28210 / 28214

页数：5

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