Histone methylation modification and diabetic kidney disease: Potential molecular mechanisms and therapeutic approaches (Review)

被引：0
|
作者：
Qu, Peng [1 ]
Li, Lanfang [1 ]
Jin, Qi [2 ]
Liu, Donghai [3 ]
Qiao, Yuan [3 ]
Zhang, Yijia [4 ]
Sun, Qiuyue [5 ]
Ran, Shuman [1 ]
Li, Zecheng [1 ]
Liu, Tongtong [2 ]
Peng, Liang [1 ]
机构：
[1] China Japan Friendship Hosp, Inst Clin Med Sci, 2 Yinghuayuan East St, Beijing 100029, Peoples R China
[2] China Acad Chinese Med Sci, Guanganmen Hosp, 5 Beixiange, Beijing 100029, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, China Japan Friendship Hosp, Beijing 100029, Peoples R China
[4] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China
[5] Beijing Univ Chinese Med, Affiliated Hosp 3, Beijing 100029, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2024年 / 54卷 / 05期
关键词：
DKD; epigenetics; histone methylation; transcriptional regulation; inhibitors; ATTENUATES RENAL FIBROSIS; LYSINE METHYLATION; INHIBITION; CANCER; NEPHROPATHY; BIOLOGY; PATHWAY; GLUCOSE; INJURY; H3K9;
D O I：
10.3892/ijmm.2024.5428
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease, and is characterized by persistent proteinuria and decreased glomerular filtration rate. Despite extensive efforts, the increasing incidence highlights the urgent need for more effective treatments. Histone methylation is a crucial epigenetic modification, and its alteration can destabilize chromatin structure, thereby regulating the transcriptional activity of specific genes. Histone methylation serves a substantial role in the onset and progression of various diseases. In patients with DKD, changes in histone methylation are pivotal in mediating the interactions between genetic and environmental factors. Targeting these modifications shows promise in ameliorating renal histological manifestations, tissue fibrosis and proteinuria, and represents a novel therapeutic frontier with the potential to halt DKD progression. The present review focuses on the alterations in histone methylation during the development of DKD, systematically summarizes its impact on various renal parenchymal cells and underscores the potential of targeted histone methylation modifications in improving DKD outcomes.
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页数：14
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