The Apelin Receptor Agonist Azelaprag Increases Weight Loss in Diet-Induced Obese Mice on Incretin Agonists and Restores Body Composition and Muscle Function to That of Lean Controls

被引:0
|
作者
Wang, Yan
Yan, Shijun
Banicki, Matthew
Cochran, Mary
Portillo, Claudia
Guerrero, Gabriel
Pan, Yong
Cowdin, Samantha
Patil, Christopher
Rebo, Justin
Hughes, Robert
Montgomery, Rusty
Morgen, Eric
Fortney, Kristen
Rubin, Paul
机构
关键词
D O I
10.2337/db24-118-OR
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
118-OR
引用
收藏
页数:2
相关论文
共 38 条
  • [31] Liraglutide and Exendin-4 Differentially Alter Body Weight Loss, Glucose Tolerance, Postprandial Dyslipidemia, and Gut Microbiota in 60% High-Fat Diet-induced Obese Mice
    Briad, Francois
    Brousseau, Emmanuel
    Lelouvier, Benjamin
    Servant, Florence
    Courtney, Michael
    Burcelin, Remy
    Sulpice, Thierry
    DIABETES, 2016, 65 : A494 - A495
  • [32] MB07811, a liver-targeted prodrug of a novel thyroid hormone receptor agonist, does not cause loss of glycemic control in Sprague Dawley rats or diet-induced obese mice
    Van Poelje, Paul D.
    Cable, Edward E.
    Yang, Xiaohong
    Ito, Bruce
    Linemeyer, David L.
    Erion, Mark D.
    DIABETES, 2007, 56 : A554 - A554
  • [33] Co-agonist of glucagon and GLP-1 reduces cholesterol and improves insulin sensitivity independent of its effect on appetite and body weight in diet-induced obese C57 mice
    Patel, Vishal
    Joharapurkar, Amit
    Dhanesha, Nirav
    Kshirsagar, Samadhan
    Patel, Kartik
    Bahekar, Rajesh
    Shah, Gaurang
    Jain, Mukul
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2013, 91 (12) : 1009 - 1015
  • [34] The novel chimeric multi-agonist peptide (GEP44) reduces energy intake and body weight in male and female diet-induced obese mice in a glucagon-like peptide-1 receptor-dependent manner
    Blevins, James E.
    Honeycutt, Mackenzie K.
    Slattery, Jared D.
    Goldberg, Matvey
    Rambousek, June R.
    Tsui, Edison
    Dodson, Andrew D.
    Ashlaw, Emily F.
    Shelton, Kyra A.
    Salemeh, Therese S.
    Elfers, Clinton T.
    Chichura, Kylie S.
    Zraika, Sakeneh
    Doyle, Robert P.
    Roth, Christian L.
    FRONTIERS IN ENDOCRINOLOGY, 2024, 15
  • [35] Chronic treatment with glucagon-like peptide-1 and glucagon receptor co-agonist causes weight loss-independent improvements in hepatic steatosis in mice with diet-induced obesity
    McGlone, Emma Rose
    Davies, Iona
    Dore, Marian
    Goldin, Rob
    Jones, Ben
    Liu, Zhigang
    V. Li, Jia
    Vorkas, Panagiotis A.
    Khoo, Bernard
    Carling, David
    Minnion, James
    Bloom, Stephen R.
    Tan, Tricia M. -M.
    BIOMEDICINE & PHARMACOTHERAPY, 2024, 176
  • [36] The Dual Glucagon and Glucagon-Like Peptide-1 Receptor (GCGR/GLP-1R) Agonist BI 4569Reduces Body Weight in Diet-Induced Obese Mice Based on Food Intake Reduction and an Increase in Energy Expenditure
    Zimmermann, Tina
    Thomas, Leo
    Baader-Pagler, Tamara
    Haebel, Peter
    Neubauer, Heike
    Simon, Eric
    Reindl, Wolfgang
    Bajrami, Besnik
    Rist, Wolfgang
    Uphues, Ingo
    Augustin, Robert
    DIABETES, 2022, 71
  • [37] Improved leptin sensitivity and increased soluble leptin receptor concentrations may underlie the additive effects of combining PYY [1-34] and exendin-4 on body weight lowering in diet-induced obese mice
    Wulff, Birgitte S.
    Kuhre, Rune Ehrenreich
    Selvaraj, Madhan
    Rehfeld, Jens F.
    Niss, Kristoffer
    Fels, Johannes J.
    Anna, Secher
    Raun, Kirsten
    Gerstenberg, Marina Kjaergaard
    HELIYON, 2024, 10 (12)
  • [38] Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a Novel Peripherally Restricted Cannabinoid-1 Receptor Antagonist with Significant Weight-Loss Efficacy in Diet-Induced Obese Mice
    Chang, Chun-Ping
    Wu, Chien-Huang
    Song, Jen-Shin
    Chou, Ming-Chen
    Wong, Ying-Chieh
    Lin, Yinchiu
    Yeh, Teng-Kuang
    Sadani, Amit A.
    Ou, Ming-Hung
    Chen, Kun-Hung
    Chen, Pei-Hsuan
    Kuo, Po-Chu
    Tseng, Chen-Tso
    Chang, Kuei-Hua
    Tseng, Shi-Liang
    Chao, Yu-Sheng
    Hung, Ming-Shiu
    Shia, Kak-Shan
    JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (24) : 9920 - 9933