Elucidation of the mechanisms of exercise-induced hypoalgesia and pain prolongation due to physical stress and the restriction of movement

被引：3

作者：

Tanaka, Kenichi ^{[1
,2
]}

Kuzumaki, Naoko ^{[1
,2
]}

Hamada, Yusuke ^{[1
,2
]}

Suda, Yukari ^{[1
,2
]}

Mori, Tomohisa ^{[1
]}

Nagumo, Yasuyuki ^{[2
]}

Narita, Minoru ^{[1
,2
]}

机构：

[1] Hoshi Univ, Dept Pharmacol, Sch Pharm & Pharmaceut Sci, 2-4-41 Ebara,Shinagawa ku, Tokyo 1428501, Japan

[2] Natl Canc Ctr, Div Canc Pathophysiol, Div Canc Pathophysiol, 5-1-1 Tsukiji,Chuo ku, Tokyo 1040045, Japan

来源：

NEUROBIOLOGY OF PAIN | 2023年 / 14卷

关键词：

Exercise -induced hypoalgesia; Stress; Pain prolongation; Brain reward system; Mesolimbic dopaminergic network; NEUROPATHIC PAIN; BACK-PAIN; RAT MODEL; DOPAMINE; SYSTEM; MODULATION; NUCLEUS; CONTRIBUTES; ACTIVATION; DEPRESSION;

D O I：

10.1016/j.ynpai.2023.100133

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Persistent pain signals cause brain dysfunction and can further prolong pain. In addition, the physical restriction of movement (e.g., by a cast) can cause stress and prolong pain. Recently, it has been recognized that exercise therapy including rehabilitation is effective for alleviating chronic pain. On the other hand, physical stress and the restriction of movement can prolong pain. In this review, we discuss the neural circuits involved in the control of pain prolongation and the mechanisms of exercise-induced hypoalgesia (EIH). We also discuss the importance of the mesolimbic dopaminergic network in these phenomena.

引用

页数：6

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