Metal-Free Cascade Formation of C-C and C-N Bond for the Construction of 3-Cyano-2-Pyridones with Insecticidal Properties

被引：2

作者：

Tang, Yao ^{[1
]}

Wu, Nvjiang ^{[1
]}

Xu, Junyu ^{[1
]}

Zhang, Xiaopo ^{[1
]}

Li, Youbin ^{[1
]}

Wang, Xuesong ^{[1
]}

机构：

[1] Hainan Med Univ, Haikou Key Lab Li Nationality Med, Engn Res Ctr Trop Med Innovat & Transformat, Int Joint Res Ctr Human Machine Intelligent Collab, Haikou 571199, Peoples R China

来源：

MOLECULES | 2024年 / 29卷 / 12期

基金：

中国国家自然科学基金;

关键词：

3-cyano-2-pyridone; insecticidal; C-C and C-N bond; construction; metal-free; cascade; REGIOSPECIFIC SYNTHESIS; BIOLOGICAL EVALUATION; 2-PYRIDONE SYNTHESIS; DERIVATIVES; CYCLOADDITION; INHIBITORS; PYRIDONES; ALKYNES; DESIGN; CYCLIZATION;

D O I：

10.3390/molecules29122792

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A straightforward and efficient methodology has been developed for the synthesis of 3-cyano-2-pyridones via the C-C and C-N bond formation processes. A total of 51 diverse 3-cyano-2-pyridone derivatives were obtained in moderate to excellent yields. This reaction featured advantages such as a metal-free process, wide functional group tolerance, simple operation, and mild conditions. A plausible mechanism for the reaction was proposed. 3-cyano-2-pyridones as ricinine analogues for insecticidal properties were evaluated, and the compound 3ci (LC50 = 2.206 mg/mL) showed the best insecticidal property.

引用

页数：18

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