Metal-Free Cascade Formation of C-C and C-N Bond for the Construction of 3-Cyano-2-Pyridones with Insecticidal Properties

被引：2
|
作者：
Tang, Yao [1 ]
Wu, Nvjiang [1 ]
Xu, Junyu [1 ]
Zhang, Xiaopo [1 ]
Li, Youbin [1 ]
Wang, Xuesong [1 ]
机构：
[1] Hainan Med Univ, Haikou Key Lab Li Nationality Med, Engn Res Ctr Trop Med Innovat & Transformat, Int Joint Res Ctr Human Machine Intelligent Collab, Haikou 571199, Peoples R China
来源：
MOLECULES | 2024年 / 29卷 / 12期
基金：
中国国家自然科学基金;
关键词：
3-cyano-2-pyridone; insecticidal; C-C and C-N bond; construction; metal-free; cascade; REGIOSPECIFIC SYNTHESIS; BIOLOGICAL EVALUATION; 2-PYRIDONE SYNTHESIS; DERIVATIVES; CYCLOADDITION; INHIBITORS; PYRIDONES; ALKYNES; DESIGN; CYCLIZATION;
D O I：
10.3390/molecules29122792
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A straightforward and efficient methodology has been developed for the synthesis of 3-cyano-2-pyridones via the C-C and C-N bond formation processes. A total of 51 diverse 3-cyano-2-pyridone derivatives were obtained in moderate to excellent yields. This reaction featured advantages such as a metal-free process, wide functional group tolerance, simple operation, and mild conditions. A plausible mechanism for the reaction was proposed. 3-cyano-2-pyridones as ricinine analogues for insecticidal properties were evaluated, and the compound 3ci (LC50 = 2.206 mg/mL) showed the best insecticidal property.
引用
收藏
页数：18
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