Metabolic reprogramming enhances expansion and potency of CAR T cells

被引:0
|
作者
Xing, Yewei
Eaker, Shannon
Bronevetsky, Yelena
Garcia, Candy
Lemar, Hadia
Massi, Evan
Wong, Albert
Barnes, Sheri
Germain, Derrik
Wise, Scott
Lim, James
机构
关键词
D O I
10.1158/1538-7445.AM2024-6334
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
6334
引用
收藏
页数:2
相关论文
共 50 条
  • [1] GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency
    Guerrero, Justin A.
    Klysz, Dorota D.
    Chen, Yiyun
    Malipatlolla, Meena
    Lone, Jameel
    Fowler, Carley
    Stuani, Lucille
    May, Audre
    Bashti, Malek
    Xu, Peng
    Huang, Jing
    Michael, Basil
    Contrepois, Kevin
    Dhingra, Shaurya
    Fisher, Chris
    Svensson, Katrin J.
    Davis, Kara L.
    Kasowski, Maya
    Feldman, Steven A.
    Sotillo, Elena
    Mackall, Crystal L.
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [2] Inosine induces stemness features in CAR-T cells and enhances potency
    Klysz, Dorota D.
    Fowler, Carley
    Malipatlolla, Meena
    Stuani, Lucille
    Freitas, Katherine A.
    Chen, Yiyun
    Meier, Stefanie
    Daniel, Bence
    Sandor, Katalin
    Xu, Peng
    Huang, Jing
    Labanieh, Louai
    Keerthi, Vimal
    Leruste, Amaury
    Bashti, Malek
    Mata-Alcazar, Janette
    Gkitsas, Nikolaos
    Guerrero, Justin A.
    Fisher, Chris
    Patel, Sunny
    Asano, Kyle
    Patel, Shabnum
    Davis, Kara L.
    Satpathy, Ansuman T.
    Feldman, Steven A.
    Sotillo, Elena
    Mackall, Crystal L.
    CANCER CELL, 2024, 42 (02) : 266 - 282.e8
  • [3] Metabolic reprogramming and metabolic dependency in T cells
    Wang, Ruoning
    Green, Douglas R.
    IMMUNOLOGICAL REVIEWS, 2012, 249 : 14 - 26
  • [4] Metabolic reprogramming of T cells in RA
    Emma Leah
    Nature Reviews Rheumatology, 2013, 9 (11) : 635 - 635
  • [5] AB-X INTEGRATED CIRCUIT T CELLS DEMONSTRATE IMPROVED POTENCY, EXPANSION, AND SPECIFICITY COMPARED TO MSLN CAR T CELLS
    Santoro, Stephen
    Cooper, Aaron
    Bezman, Natalie
    Feng, Jun
    Chawla, Kanika
    Williams, Jaspar
    Gagnon, John
    Hall, Jason
    Polyak, Dina
    Boroughs, Angela
    Nguyen, Michelle
    Mohanty, Suchismita
    Litterman, Adam
    Granja, Jeff
    DeTomaso, David
    Zheng, Grace
    Smith, Jenessa
    LeFace, Drake
    Mikkelsen, Tarjei
    Jun, Susie
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A226 - A226
  • [6] Metabolic reprogramming in inflammaging and aging in T cells
    Bevilacqua, Alessio
    Ho, Ping-Chih
    Franco, Fabien
    LIFE METABOLISM, 2023, 2 (05):
  • [7] Metabolic reprogramming in inflammaging and aging in T cells
    Alessio Bevilacqua
    PingChih Ho
    Fabien Franco
    Life Metabolism, 2023, 2 (05) : 217 - 224
  • [8] HIV immune evasin Nef enhances allogeneic CAR T cell potency
    Karlo Perica
    Ivan S. Kotchetkov
    Jorge Mansilla-Soto
    Fiona Ehrich
    Kevin Herrera
    Yuzhe Shi
    Anton Dobrin
    Mithat Gönen
    Michel Sadelain
    Nature, 2025, 640 (8059) : 793 - 801
  • [9] Runx2 Overexpression Enhances Potency and Counteracts Exhaustion in CD8+CAR T Cells
    Degolier, Kole R.
    Danis, Etienne
    Cimons, Jennifer
    Yarnell, Michael
    Kedl, Ross
    Kohler, M. Eric
    Scott-Browne, James
    Fry, Terry J.
    BLOOD, 2023, 142
  • [10] Metabolic engineering of CAR-T cells overcomes suppressive adenosine signaling and enhances functionality
    Klysz, Dorota
    Malipatlolla, Meena
    Freitas, Katherine
    Bashti, Malek
    Labanieh, Louai
    Xu, Peng
    Ramello, Cecilia
    Lerust, Amaury
    Want, Hyatt Balke
    Pacheco, Kaithlen Zen
    Weber, Evan W.
    Patel, Shabnum
    Feldman, Steven
    Sotillo, Elena
    Mackall, Crystal L.
    CANCER RESEARCH, 2022, 82 (12)