Status of breast cancer detection in young women and potential of liquid biopsy

被引:1
|
作者
Stibbards-Lyle, Maya [1 ,2 ]
Malinovska, Julia [1 ,2 ]
Badawy, Seleem [1 ,2 ]
Schedin, Pepper [3 ]
Rinker, Kristina D. [1 ,2 ,4 ,5 ]
机构
[1] Univ Calgary, Schulich Sch Engn, Dept Biomed Engn, Calgary, AB, Canada
[2] Univ Calgary, Cellular & Mol Bioengn Res Lab, Calgary, AB, Canada
[3] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR USA
[4] Univ Calgary, Arnie Charbonneau Canc Inst, Calgary, AB, Canada
[5] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB, Canada
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词
breast cancer; young women; postpartum; involution; liquid biopsy; molecular diagnostics; early detection; FLUID SHEAR-STRESS; MAMMARY-GLAND INVOLUTION; PATHOLOGICAL CHARACTERISTICS; DIAGNOSTIC PERFORMANCE; EPITHELIAL-CELLS; WORSE PROGNOSIS; GENE-EXPRESSION; SEX-HORMONES; TUMOR SIZE; HIGH-RISK;
D O I
10.3389/fonc.2024.1398196
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Young onset breast cancer (YOBC) is an increasing demographic with unique biology, limited screening, and poor outcomes. Further, women with postpartum breast cancers (PPBCs), cancers occurring up to 10 years after childbirth, have worse outcomes than other young breast cancer patients matched for tumor stage and subtype. Early-stage detection of YOBC is critical for improving outcomes. However, most young women (under 45) do not meet current age guidelines for routine mammographic screening and are thus an underserved population. Other challenges to early detection in this population include reduced performance of standard of care mammography and reduced awareness. Women often face significant barriers in accessing health care during the postpartum period and disadvantaged communities face compounding barriers due to systemic health care inequities. Blood tests and liquid biopsies targeting early detection may provide an attractive option to help address these challenges. Test development in this area includes understanding of the unique biology involved in YOBC and in particular PPBCs that tend to be more aggressive and deadly. In this review, we will present the status of breast cancer screening and detection in young women, provide a summary of some unique biological features of YOBC, and discuss the potential for blood tests and liquid biopsy platforms to address current shortcomings in timely, equitable detection.
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页数:14
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