Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis

被引：1
|
作者：
Hasan, Faizul [1 ]
Chiu, Hsiao-Yean [1 ]
Salamanca, Eisner [2 ]
Ridwan, Edi S. [3 ]
Wiratama, Bayu S. [4 ]
Budi, Hendrik S. [5 ]
机构：
[1] Taipei Med Univ, Sch Nursing, Coll Nursing, Taipei, Taiwan
[2] Taipei Med Univ, Sch Dent, Coll Dent, Taipei, Taiwan
[3] Alma Ata Univ, Sch Nursing, Fac Hlth Sci, Alma Ata, Indonesia
[4] Univ Gadjah Mada, Dept Epidemiol Biostat & Populat Hlth, Fac Med, Yogyakarta City, Indonesia
[5] Airlangga Univ, Fac Med Dent, Dept Oral Biol, Dent Pharmacol, Jl Mayjend Prof Dr Moestopo 47, Surabaya 60132, Indonesia
来源：
EUROPEAN JOURNAL OF DENTISTRY | 2023年 / 17卷 / 03期
关键词：
mouthwash; oral health; viral load; cycle threshold; infectious disease; MOUTHWASHES; COVID-19; SARS;
D O I：
10.1055/s-0042-1753470
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The efficacy of mouthwash for reducing the viral load in patients with the novel coronavirus disease 2019 (COVID-19) remains unclear. This systematic review and meta-analysis comprehensively examined the effects of chlorhexidine (CHX) and povidone-iodine (PVP-I) on the viral load in patients with COVID-19. We performed methodological analysis, systematic review, and meta-analysis of included studies using the Comprehensive Meta-analysis Software. PubMed, EMBASE, Cochrane Library, and ProQuest were searched from December 1, 2019, to December 2, 2021. In total, we included 10 studies of 1,339 patients with COVID-19. Compared with the control group, both CHX and PVP-I significantly reduced the number of negative reverse-transcription polymerase chain reaction (RT-PCR) results ( p <0.001) among COVID-19 patients. The CHX and PVP-I were effective on reducing the number of negative RT-PCR results in COVID-19 patients. Additional studies using adequate randomization methods and larger samples are warned.
引用
收藏
页码：587 / 601
页数：15
相关论文
共 50 条
  • [41] In Vitro Efficacy of a Povidone-Iodine Nasal Antiseptic for Rapid Inactivation of SARS-CoV-2
    Frank, Samantha
    Brown, Seth M.
    Capriotti, Joseph A.
    Westover, Jonna B.
    Pelletier, Jesse S.
    Tessema, Belachew
    JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2020, 146 (11) : 1054 - 1058
  • [42] Reducing the risk of infection for transrectal prostate biopsy with povidone-iodine: a systematic review and meta-analysis
    Pu, Chunxiao
    Bai, Yunjin
    Yuan, Haichao
    Li, Jinhong
    Tang, Yin
    Wang, Jia
    Wei, Qiang
    Han, Ping
    INTERNATIONAL UROLOGY AND NEPHROLOGY, 2014, 46 (09) : 1691 - 1698
  • [43] Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: A meta-analysis
    Chaiyakunapruk, N
    Veenstra, DL
    Lipsky, BA
    Saint, S
    ANNALS OF INTERNAL MEDICINE, 2002, 136 (11) : 792 - 801
  • [44] Effectiveness of chlorhexidine versus povidone-iodine for preventing surgical site wound infection: A meta-analysis
    Wang, Panfeng
    Wang, Dandan
    Zhang, Lingqiao
    INTERNATIONAL WOUND JOURNAL, 2024, 21 (02)
  • [45] Inactivation of SARS-CoV-2 by povidone-iodine products: implications for effective mouth rinsing and gargling
    Kariwa, Hiroaki
    Fujii, Nobuhiro
    Takashima, Ikuo
    JAPANESE JOURNAL OF VETERINARY RESEARCH, 2021, 69 (03) : 183 - 187
  • [46] In vivo (human) and in vitro inactivation of SARS-CoV-2 with 0.5% povidone-iodine nasal spray
    Friedland, Peter
    Tucker, Simon
    Goodall, Stephen
    Julander, Justin
    Mendenhall, Michelle
    Molloy, Peter
    Jong, Douwe Marcus de
    Musungaie, Dany Badibanga
    Sikazwe, Chisha
    Panta, Kirtu
    Levy, Avram
    Smith, David
    AUSTRALIAN JOURNAL OF OTOLARYNGOLOGY, 2022, 5
  • [47] Povidone-iodine functionalized nanofibers are prophylactic and protect against dissemination of SARS-CoV-2 infection
    Divin, R.
    Vojacek, V.
    Sopko, B.
    Pashchenko, A.
    Varga, J.
    Necas, A.
    Celer, V.
    Filipejova, Z.
    Urbanova, L.
    Rulc, J.
    Krajnikova, M.
    Jarosikova, T.
    Amler, E.
    EPIDEMIOLOGIE MIKROBIOLOGIE IMUNOLOGIE, 2024, 73 (02): : 98 - 105
  • [48] SARS-CoV-2 Reinfection and Severity of the Disease: A Systematic Review and Meta-Analysis
    Nguyen, Nhu Ngoc
    Nguyen, Y. Ngoc
    Hoang, Van Thuan
    Million, Matthieu
    Gautret, Philippe
    VIRUSES-BASEL, 2023, 15 (04):
  • [49] COLCHICINE TREATMENT IN SARS-COV-2 INFECTION: A SYSTEMATIC REVIEW AND META-ANALYSIS
    Beran, Azizullah Beran
    Mhanna, Mohammed
    Waseem, Wahood
    Ghazaleh, Sami
    Sajdeya, Omar
    Kalifa, Muhamad
    Ayesh, Hazem
    Srour, Omar
    Mhanna, Asmaa
    Altorok, Nezam
    Assaly, Ragheb
    CHEST, 2021, 160 (04) : 521A - 521A
  • [50] Colorectal cancer in patients with SARS-CoV-2: a systematic review and meta-analysis
    Saad Alhumaid
    Abbas Al Mutair
    Jawad S. Busubaih
    Nourah Al Dossary
    Murtadha Alsuliman
    Sarah A. Baltyour
    Ibrahim Alissa
    Hassan I. Al Hassar
    Noor A. Al Aithan
    Hani A. Albassri
    Suliman A. AlOmran
    Raed M. ALGhazal
    Ahmed Busbaih
    Nasser A. Alsalem
    Waseem Alagnam
    Mohammed Y. Alyousef
    Abdulaziz U. Alseffay
    Hussain A. Al Aish
    Ali Aldiaram
    Hisham A. Al eissa
    Murtadha A. Alhumaid
    Ali N. Bukhamseen
    Koblan M. Al mutared
    Abdullah H. Aljwisim
    Abdullah M. Twibah
    Meteab M. AlSaeed
    Hussien A. Alkhalaf
    Fatemah M. ALShakhs
    Thoyaja Koritala
    Jaffar A. Al-Tawfiq
    Kuldeep Dhama
    Ali A. Rabaan
    Awad Al-Omari
    Infectious Agents and Cancer, 17
12345