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CHARMM GUI Membrane Builder for oxidized phospholipid membrane modeling and simulation
被引:3
|作者:
Brown, Turner P.
[1
]
Santa, Dane E.
[2
]
Berger, Brett A.
[2
]
Kong, Lingyang
[3
]
Wittenberg, Nathan J.
[2
]
Im, Wonpil
[1
,2
,3
]
机构:
[1] Lehigh Univ, Dept Bioengn, Bethlehem, PA 18015 USA
[2] Lehigh Univ, Dept Chem, Bethlehem, PA 18015 USA
[3] Lehigh Univ, Dept Biol Sci, Bethlehem, PA 18015 USA
关键词:
LIPID-BILAYERS;
MOLECULAR-DYNAMICS;
FORCE-FIELD;
CD36;
OXIDATION;
RECEPTOR;
LIGANDS;
PEROXIDATION;
D O I:
10.1016/j.sbi.2024.102813
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Oxidative stress leads to the production of oxidized phospholipids (oxPLs) that modulate the biophysical properties of phospholipid monolayers and bilayers. As many immune cells are responsible for surveilling cells and tissues for the presence of oxPLs, oxPL-dependent mechanisms have been suggested as targets for treating chronic kidney disease, atherosclerosis, diabetes, and cancer metastasis. This review details recent experimental and computational studies that characterize oxPLs' behaviors in various monolayers and bilayers. These studies investigate how the tail length and polar functional groups of OxPLs impact membrane properties, how oxidized membranes can be stabilized, and how membrane integrity is generally affected by oxidized lipids. In addition, for oxPL-containing membrane modeling and simulation, CHARMM-GUI Membrane Builder has been extended to support a variety of oxPLs, accelerating the simulation system building process for these biologically relevant lipid bilayers.
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页数:7
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