Ethanol promotes protease activated receptor 1: Chemokine (C-X-C motif) receptor 4 heteromerization and enhances thrombin-induced impairment of human lung endothelial cell barrier function

被引：1

作者：

McGee, Michelle Y. ^{[1
]}

Enten, Garrett A. ^{[1
]}

Boshra, Sadia N. ^{[1
,2
]}

Ogunsina, Ololade ^{[1
]}

Gaponenko, Vadim ^{[3
]}

Gao, Xianlong ^{[1
]}

Majetschak, Matthias ^{[1
,4
]}

机构：

[1] Univ S Florida, Morsani Coll Med, Dept Surg, Tampa, FL USA

[2] Univ S Florida, Dept Chem, Tampa, FL USA

[3] Univ Illinois, Dept Biochem & Mol Genet, Chicago, IL USA

[4] Univ S Florida, Morsani Coll Med, Dept Mol Pharmacol & Physiol, Tampa, FL USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2024年 / 1870卷 / 07期

基金：

美国国家卫生研究院;

关键词：

RESPIRATORY-DISTRESS-SYNDROME; ALCOHOL-CONSUMPTION; INJURY;

D O I：

10.1016/j.bbadis.2024.167335

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

- Ethanol enhances the propensity of PAR1 and CXCR4 to form heteromers.- Ethanol increases PAR1:CXCR4 heteromer expression in human lung microvascular endothelial cells (HULEC-5a).- Ethanol enhances the efficacy of PAR1 to activate G alpha 12 upon thrombin stimulation in cells co-expressing CXCR4.- Ethanol dose-dependently increases the efficacy of thrombin to impair HULEC-5a barrier function at clinically relevant concentrations.- Interference with PAR1:CXCR4 heteromerization mitigates effects of ethanol on thrombin-induced impairment of HULEC-5a barrier function.- Our findings provide a molecular mechanism that is likely to contribute to the increased risk of acute respiratory distress syndrome with alcohol abuse.

引用

页数：4

共 50 条

[31] The prognostic value of C-X-C chemokine receptor 4 in non-small cell lung cancer: a meta-analysis
Bai, Lu
Guo, Chihua
Wu, Huanghui
Kaye, Alan David
Jin, Chenwang
Deng, Lei
Wang, Jiansheng
Guo, Youmin
Duan, Xiaoyi
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (02): : 2285 - 2295
[32] MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis
Yan, Yali
Zhu, Mengmeng
Ma, Jialing
He, Xiaoyu
Yang, Xiaoxiao
Xu, Hongmei
Jiang, Meixiu
Zhang, Shuang
Duan, Yajun
Han, Jihong
Chen, Yuanli
BIOENGINEERED, 2022, 13 (04) : 11214 - 11227
[33] Abnormal expression of fibrosis markers, estrogen receptor α and stromal derived factor-1/chemokine (C-X-C motif) receptor-4 axis in intrauterine adhesions
Zhou, Qin
Wu, Xixi
Hu, Jianguo
Yuan, Rui
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 42 (01) : 81 - 90
[34] β-Adrenoceptor Agonists Attenuate Thrombin-Induced Impairment of Human Lung Endothelial Cell Barrier Function and Protect the Lung Vascular Barrier during Resuscitation from Hemorrhagic Shock
McGee, Michelle Y.
Ogunsina, Ololade
Boshra, Sadia N.
Gao, Xianlong
Majetschak, Matthias
BIOMEDICINES, 2024, 12 (08)
[35] Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating c-x-c motif chemokine receptor 4 (vol 38, 53, 2018)
He, Liru
Deng, Haixia
Liu, Shiliang
Chen, Jiewei
Li, Binkui
Wang, Chenyuan
Wang, Xin
Liu, Mengzhong
Xie, Dan
Jiang, Yiguo
Ma, Ningfang
CANCER COMMUNICATIONS, 2021, 41 (11) : 1246 - 1247
[36] MECHANISMS OF PROTEIN KINASE C DELTA-MEDIATED REGULATION OF THROMBIN-INDUCED HUMAN LUNG ENDOTHELIAL CELL BARRIER DISRUPTION
Xie, L.
Chiang, E. T.
Kanteti, P.
Camp, S. M.
Dudek, S. M.
Natarajan, V.
Garcia, J. G.
Jacobson, J. R.
Xie, L.
Chiang, E. T.
Kanteti, P.
Camp, S. M.
Dudek, S. M.
Natarajan, V.
Garcia, J. G.
Jacobson, J. R.
Singleton, P. A.
JOURNAL OF INVESTIGATIVE MEDICINE, 2013, 61 (04) : 798 - 798
[37] Induction of endothelial proliferation and angiogenesis through activating the ERK1/2/EGF pathway mediate by CXC chemokine receptor 2 by chemokine (C-X-C motif) ligand 1
Miyake, Makito
Goodison, Steve
Gomes, Evan
Rizwani, Wasia
Ross, Shanti
Zhang, Ge
Rosser, Charles Joel
JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (06)
[38] G protein activation via chemokine (C-X-C motif) receptor 4 and α1b-adrenoceptor is ligand and heteromer-dependent
Gao, Xianlong
Majetschak, Matthias
FEBS LETTERS, 2023, 597 (15) : 2017 - 2027
[39] α1B/D-ADRENERGIC RECEPTORS CONTROL CHEMOKINE (C-X-C MOTIF) RECEPTOR 4-MEDIATED CHEMOTAXIS IN THE HUMAN MONOCYTIC CELL LINE THP1
Enten, Garrett A.
Gao, Xianlong
Majetschak, Matthias
SHOCK, 2020, 53 : 62 - 62
[40] WNT1-inducible signaling pathway protein 1 activation through C-X-C motif chemokine ligand 5/C-X-C chemokine receptor type 2/leukemia inhibitory factor/leukemia inhibitory factor receptor signaling promotes immunosuppression and neuroendocrine differentiation in prostate cancer
Tsui, Ke Hung
Liu, Chien-Liang
Yeh, Hsiu-Lien
Liu, Ming-Kun
Li, Chien-Hsiu
Chen, Wei-Hao
Jiang, Kuo-Ching
Li, Han-Ru
Dung, Phan Vu Thuy
Hsiao, Michael
Abou-Kheir, Wassim
Liu, Yen-Nien
ISCIENCE, 2024, 27 (08)

← 1 2 3 4 5 →