Analytical challenges in omics research on asthma and allergy: A National Institute of Allergy and Infectious Diseases workshop

被引：5

作者：

Bunyavanich, Supinda ^{[1
]}

Becker, Patrice M. ^{[2
]}

Altman, Matthew C. ^{[3
]}

Lasky-Su, Jessica ^{[4
,5
]}

Ober, Carole ^{[6
]}

Zengler, Karsten ^{[7
]}

Berdyshev, Evgeny ^{[8
]}

Bonneau, Richard ^{[9
]}

Chatila, Talal ^{[5
,10
]}

Chatterjee, Nilanjan ^{[11
]}

Chung, Kian Fan ^{[12
]}

Cutcliffe, Colleen ^{[13
]}

Davidson, Wendy ^{[2
]}

Dong, Gang ^{[2
]}

Fang, Gang ^{[1
]}

Fulkerson, Patricia ^{[2
]}

Himes, Blanca E. ^{[14
]}

Liang, Liming ^{[15
]}

Mathias, Rasika A. ^{[11
]}

Ogino, Shuji ^{[4
,5
,15
,16
]}

Petrosino, Joseph ^{[17
]}

Price, Nathan D. ^{[18
]}

Schadt, Eric ^{[1
]}

Schofield, James ^{[19
]}

Seibold, Max A. ^{[20
]}

Steen, Hanno ^{[5
]}

Wheatley, Lisa ^{[2
]}

Zhang, Hongmei ^{[21
]}

Togias, Alkis ^{[2
]}

Hasegawa, Kohei ^{[5
,22
]}

机构：

[1] Icahn Sch Med Mt Sinai, 1425 Madison Ave 1498, New York, NY 10029 USA

[2] NIAID, NIH, Rockville, MD USA

[3] Univ Washington, Seattle, WA USA

[4] Brigham & Womens Hosp, Boston, MA USA

[5] Harvard Med Sch, Boston, MA USA

[6] Univ Chicago, Chicago, IL USA

[7] Univ Calif San Diego, San Diego, CA USA

[8] Natl Jewish Hlth, Denver, CO USA

[9] Genentech Inc, New York, NY USA

[10] Boston Childrens Hosp, Boston, MA 02115 USA

[11] Johns Hopkins Univ, Baltimore, MD USA

[12] Imperial Coll London, London, England

[13] Pendulum Therapeut, San Francisco, CA USA

[14] Univ Penn, Philadelphia, PA USA

[15] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

[16] Broad Inst MIT & Harvard, Boston, MA USA

[17] Baylor Coll Med, Houston, TX USA

[18] Thorne Healthtech, New York, NY USA

[19] Univ Southampton, Southampton, England

[20] Univ Colorado, Sch Med, Aurora, CO USA

[21] Univ Memphis, Sch Publ Hlth, Memphis, TN USA

[22] Massachusetts Gen Hosp, Boston, MA USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2024年 / 153卷 / 04期

关键词：

Omics; genomics; epigenomics; transcriptomics; micro-; biome; proteomics; metabolomics; lipidomics; integrative; systems biology; causal inference; asthma; allergy; allergic diseases; GENOME-WIDE ASSOCIATION; PROBE DESIGN BIAS; COLORECTAL-CANCER; RISK; MICROBIOME; BLOOD; NORMALIZATION; METAANALYSIS; RESOURCE; DIETARY;

D O I：

10.1016/j.jaci.2024.01.014

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Studies of asthma and allergy are generating increasing volumes of omics data for analysis and interpretation. The National Institute of Allergy and Infectious Diseases (NIAID) assembled a workshop comprising investigators studying asthma and allergic diseases using omics approaches, omics investigators from outside the field, and NIAID medical and scientific officers to discuss the following areas in asthma and allergy research: genomics, epigenomics, transcriptomics, microbiomics, metabolomics, proteomics, lipidomics, integrative omics, systems biology, and causal inference. Current states of the art, present challenges, novel and emerging strategies, and priorities for progress were presented and discussed for each area. This workshop report summarizes the major points and conclusions from this NIAID workshop. As a group, the investigators underscored the imperatives for rigorous analytic frameworks, integration of different omics data types, cross -disciplinary interaction, strategies for overcoming current limitations, and the overarching goal to improve scientific understanding and care of asthma and allergic diseases. (J Allergy Clin Immunol 2024;153:954-68.)

引用

页码：954 / 968

页数：15

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