Reaction of Isatin and 2-Chloropyridinium Salt: An Efficient and Diastereoselective Synthesis of α,β-Unsaturated Oxindoles

被引：0

作者：

Imani, Kaveh ^{[1
]}

Shirazi, Hamideh ^{[1
]}

Golchin, Golnaz ^{[1
]}

Bazgir, Ayoob ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Dept Organ Chem, Tehran 1983969411, Iran

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 19期

关键词：

INHIBITORS; DESIGN; INDOLINONES; PYRIDONE; KINASE;

D O I：

10.1021/acs.joc.4c01069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, mild, and diastereoselective method has been developed for the synthesis of beta-pyridone-alpha,beta-unsaturated oxindoles by the reaction of isatins and 2-chloropyridinium salts in EtOH at room temperature for 5 min. This method operates under mild reaction conditions, providing the product with a good yield and diastereoselectivity, and it exhibits excellent tolerance toward various functional groups. The predominant isomer is the Z isomer, which can convert to the E isomer in the presence of NaN3.

引用

页码：13937 / 13946

页数：10

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