Synthesis, Characterization and Biological Activity of Novel Heterocyclic Compounds Containing Acylated Pyrazoline

A set of novel acylated pyrazoline compounds 3(a-i) was prepared and structural elucidation was confirmed by using spectroscopic techniques such as 1 H-NMR, FT-IR, and mass spectroscopy. Progress of the reaction was monitored by TLC. The synthesized set of acylated pyrazoline compounds 3(a-i) was evaluated for antimicrobial screening which reveals that these compounds have interesting properties. The discs diffusion method was utilized to perform In -vitro antimicrobial activity of pyrazoline derivatives 3(a-i) against Escherichia coli (MCC -2412), Staphylococcus aureus (MCC -2408), B. subtilis (MCC -2010), P. aeruginosa (MCC -2080), Saccharomyces cerevisiae (MCC -1033), and Candida albicans (MCC -1439). Some of the acylated molecules such as 3c, 3d, 3g and 3e emerged as excellent designs represents comparable or higher antimicrobial activities concerning standard drug candidates.