BrOnsted Acid Catalyzed Intramolecular Allylic Substitution Reaction of Allylic Alcohols: A Facile Synthesis of 2-Vinylchromans

被引：0

作者：

Li, Yun-Fan ^{[1
]}

Xi, Yu-Ting ^{[1
]}

Hu, Kai-Ji ^{[1
]}

Tan, Qitao ^{[1
]}

Ding, Chang-Hua ^{[1
]}

Xu, Bin ^{[1
,2
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai Engn Res Ctr Organ Repair, Innovat Drug Res Ctr, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

SYNLETT | 2024年 / 35卷 / 18期

关键词：

BrOnsted acid; allylic substitution reaction; allylic alcohol; chroman; metal-free reactions; ASYMMETRIC-SYNTHESIS; ALKYLATION; CHROMANS; TERTIARY; PHENOLS; CYCLOADDITION; HETEROCYCLES; ALLYLATION; ANNULATION; FLAVONOIDS;

D O I：

10.1055/a-2301-9223

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bronsted acid-catalyzed intramolecular allylic substitution reaction of secondary and tertiary allylic alcohols has been developed. A variety of 2-vinylchromans were efficiently prepared in moderate to excellent yields. The given method features wide substrate scope, operational simplicity, metal-free, and mild reaction conditions. The practicability of the method was demonstrated by the gram-scale reaction and further derivations of the product. Catalytic asymmetric reaction was preliminarily studied. © 2024 Georg Thieme Verlag. All rights reserved.

引用

页码：2148 / 2152

页数：5

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