Chiral Bronsted Acid-Catalyzed Kinetic Resolution of Sulfoximines for the Synthesis of Benzothiadiazine-1-Oxides

被引：1

作者：

Chen, Yuhang ^{[1
]}

Huang, Shihao ^{[1
]}

Wang, Tianyi ^{[1
]}

Li, Jiaomeng ^{[1
]}

Zhao, Yi ^{[1
]}

Zhou, Qinglong ^{[1
]}

Wei, Liwen ^{[1
]}

Yang, Xing ^{[1
]}

机构：

[1] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Assembly & Applicat Organ Funct Mol Hunan, Key Lab Chem Biol & Tradit Chinese Med,Minist Educ, Changsha 410081, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Amination; -; Amines; Scaffolds; Stereochemistry;

D O I：

10.1021/acs.joc.4c00623

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzothiadiazine-1-oxide scaffolds with S-stereogenic centers are prevalent in bioactive and pharmaceutical molecules. Reported works mainly focused on the metal-catalyzed asymmetric C-H amination/cyclization reaction for the synthesis of benzothiadiazine-1-oxides. Here, we reported a chiral phosphoric acid-catalyzed kinetic resolution of sulfoximines, providing chiral benzothiadiazine-1-oxides and recovered chiral sulfoximines with moderate to good enantioselectivities (s factors up to 36.6).

引用

页码：7970 / 7981

页数：12

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