Systematic Review of Cerebrospinal Fluid Biomarker Discovery in Neuro-Oncology: A Roadmap to Standardization and Clinical Application

被引:5
|
作者
Mikolajewicz, Nicholas [1 ,2 ]
Yee, Patricia P. [3 ]
Bhanja, Debarati [4 ]
Trifoi, Mara [4 ]
Miller, Alexandra M. [5 ]
Metellus, Philippe [6 ]
Bagley, Stephen J. [7 ]
Balaj, Leonora [8 ]
de Macedo Filho, Leonardo J. M. [4 ]
Zacharia, Brad E. [4 ]
Aregawi, Dawit [4 ]
Glantz, Michael [4 ]
Weller, Michael [9 ,10 ]
Ahluwalia, Manmeet S. [11 ,12 ]
Kislinger, Thomas [13 ,14 ]
Mansouri, Alireza [4 ]
机构
[1] Hosp Sick Children, Peter Gilgan Ctr Res & Learning, Toronto, ON, Canada
[2] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
[3] Penn State Coll Med, Med Scientist Training Program, Hershey, PA USA
[4] Penn State Milton S Hershey Med Ctr, Dept Neurosurg, Hershey, PA 17033 USA
[5] Mem Sloan Kettering Canc Ctr, Dept Neurol & Pediat, New York, NY USA
[6] Hop Pr Clairval, Dept Neurosurg, Ramsay Sante, Marseille, France
[7] Univ Penn, Perelman Sch Med, Philadelphia, PA USA
[8] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA USA
[9] Univ Hosp Zurich, Dept Neurol, Zurich, Switzerland
[10] Univ Zurich, Dept Neurol, Zurich, Switzerland
[11] Baptist Hlth South Florida, Miami Canc Inst, Miami, FL USA
[12] Herbert Wertheim Coll Med, Florida Int Univ, Miami, FL USA
[13] Princess Margaret Canc Ctr, Toronto, ON, Canada
[14] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
关键词
CENTRAL-NERVOUS-SYSTEM; CIRCULATING TUMOR DNA; BRAIN-BARRIER DISRUPTION; DIAGNOSTIC BIOMARKER; STEREOTACTIC BIOPSY; PROTEOMIC ANALYSIS; MASS-SPECTROMETRY; FROZEN-SECTION; CSF; PROTEIN;
D O I
10.1200/JCO.23.01621
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Effective diagnosis, prognostication, and management of CNS malignancies traditionally involves invasive brain biopsies that pose significant risk to the patient. Sampling and molecular profiling of cerebrospinal fluid (CSF) is a safer, rapid, and noninvasive alternative that offers a snapshot of the intracranial milieu while overcoming the challenge of sampling error that plagues conventional brain biopsy. Although numerous biomarkers have been identified, translational challenges remain, and standardization of protocols is necessary. Here, we systematically reviewed 141 studies (Medline, SCOPUS, and Biosis databases; between January 2000 and September 29, 2022) that molecularly profiled CSF from adults with brain malignancies including glioma, brain metastasis, and primary and secondary CNS lymphomas. We provide an overview of promising CSF biomarkers, propose CSF reporting guidelines, and discuss the various considerations that go into biomarker discovery, including the influence of blood-brain barrier disruption, cell of origin, and site of CSF acquisition (eg, lumbar and ventricular). We also performed a meta-analysis of proteomic data sets, identifying biomarkers in CNS malignancies and establishing a resource for the research community.
引用
收藏
页码:1961 / 1974
页数:15
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