Impact of bariatric surgery on circulating irisin levels: a systematic review and meta-analysis

被引:1
|
作者
Jamialahamdi, Tannaz [1 ,2 ]
Mirhadi, Elaheh [3 ]
Almahmeed, Wael [4 ]
Eid, Ali H. [5 ]
Al-Rasadi, Khalid [6 ,7 ]
Nguyen, Ninh T. [8 ]
Gadde, Kishore M. [8 ]
Sahebkar, Amirhossein [9 ,10 ,11 ]
机构
[1] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran
[2] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Mashhad, Iran
[3] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran
[4] Cleveland Clin Abu Dhabi, Heart & Vasc Inst, Abu Dhabi, U Arab Emirates
[5] Qatar Univ, QU Hlth, Coll Med, Dept Basic Med Sci, Doha, Qatar
[6] Sultan Qaboos Univ, Med Res Ctr, Muscat, Oman
[7] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Biochem, Muscat, Oman
[8] Univ Calif Irvine, Med Ctr, Dept Surg, Orange, CA USA
[9] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Chennai, India
[10] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran
[11] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran
关键词
Bariatric surgery; Irisin levels; Roux-en-Y gastric bypass; Sleeve gastrectomy; FNDC5; EXPRESSION; WEIGHT;
D O I
10.1007/s13304-024-01866-8
中图分类号
R61 [外科手术学];
学科分类号
摘要
This systematic review and meta-analysis evaluated changes in circulating irisin levels after bariatric surgery. A systematic search was performed across Embase, Scopus, PubMed, and Web of Science for this study. The meta-analysis was conducted using Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was depicted through a random-effects meta-analysis and the leave-one-out method. The meta-analysis, which included 13 studies with a total of 407 participants, showed a statistically non-significant reduction in circulating irisin levels following bariatric surgery (SMD: - 0.089, 95% CI - 0.281, 0.102, 95% PI: - 0.790, 0.611, p = 0.360; I2:70.56). Our research found no significant change in irisin levels after bariatric surgery. Moreover, these findings were not associated with the type of surgery or the duration of follow-up.
引用
收藏
页码:2745 / 2754
页数:10
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