Impact of bariatric surgery on circulating irisin levels: a systematic review and meta-analysis

被引：1

作者：

Jamialahamdi, Tannaz ^{[1
,2
]}

Mirhadi, Elaheh ^{[3
]}

Almahmeed, Wael ^{[4
]}

Eid, Ali H. ^{[5
]}

Al-Rasadi, Khalid ^{[6
,7
]}

Nguyen, Ninh T. ^{[8
]}

Gadde, Kishore M. ^{[8
]}

Sahebkar, Amirhossein ^{[9
,10
,11
]}

机构：

[1] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran

[2] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Mashhad, Iran

[3] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran

[4] Cleveland Clin Abu Dhabi, Heart & Vasc Inst, Abu Dhabi, U Arab Emirates

[5] Qatar Univ, QU Hlth, Coll Med, Dept Basic Med Sci, Doha, Qatar

[6] Sultan Qaboos Univ, Med Res Ctr, Muscat, Oman

[7] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Biochem, Muscat, Oman

[8] Univ Calif Irvine, Med Ctr, Dept Surg, Orange, CA USA

[9] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Chennai, India

[10] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran

[11] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran

来源：

UPDATES IN SURGERY | 2024年 / 76卷 / 08期

关键词：

Bariatric surgery; Irisin levels; Roux-en-Y gastric bypass; Sleeve gastrectomy; FNDC5; EXPRESSION; WEIGHT;

D O I：

10.1007/s13304-024-01866-8

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This systematic review and meta-analysis evaluated changes in circulating irisin levels after bariatric surgery. A systematic search was performed across Embase, Scopus, PubMed, and Web of Science for this study. The meta-analysis was conducted using Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was depicted through a random-effects meta-analysis and the leave-one-out method. The meta-analysis, which included 13 studies with a total of 407 participants, showed a statistically non-significant reduction in circulating irisin levels following bariatric surgery (SMD: - 0.089, 95% CI - 0.281, 0.102, 95% PI: - 0.790, 0.611, p = 0.360; I2:70.56). Our research found no significant change in irisin levels after bariatric surgery. Moreover, these findings were not associated with the type of surgery or the duration of follow-up.

引用

页码：2745 / 2754

页数：10

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