Radiopharmaceuticals for Skeletal Muscle PET Imaging

被引:2
|
作者
Park, Joo Yeon [1 ]
Park, Sun Mi [1 ]
Lee, Tae Sup [2 ]
Kang, Seo Young [1 ]
Kim, Ji-Young [1 ]
Yoon, Hai-Jeon [1 ]
Kim, Bom Sahn [1 ]
Moon, Byung Seok [1 ]
机构
[1] Ewha Womans Univ, Coll Med, Dept Nucl Med, Seoul 07804, South Korea
[2] Korea Inst Radiol & Med Sci, Div RI Applicat, Seoul 01812, South Korea
基金
新加坡国家研究基金会;
关键词
positron emission tomography; radiopharmaceutical; skeletal muscle atrophy; GLUCOSE-UPTAKE; BLOOD-FLOW; MANAGEMENT; MECHANISMS;
D O I
10.3390/ijms25094860
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The skeletal muscles account for approximately 40% of the body weight and are crucial in movement, nutrient absorption, and energy metabolism. Muscle loss and decline in function cause a decrease in the quality of life of patients and the elderly, leading to complications that require early diagnosis. Positron emission tomography/computed tomography (PET/CT) offers non-invasive, high-resolution visualization of tissues. It has emerged as a promising alternative to invasive diagnostic methods and is attracting attention as a tool for assessing muscle function and imaging muscle diseases. Effective imaging of muscle function and pathology relies on appropriate radiopharmaceuticals that target key aspects of muscle metabolism, such as glucose uptake, adenosine triphosphate (ATP) production, and the oxidation of fat and carbohydrates. In this review, we describe how [18F]fluoro-2-deoxy-D-glucose ([18F]FDG), [18F]fluorocholine ([18F]FCH), [11C]acetate, and [15O]water ([15O]H2O) are suitable radiopharmaceuticals for diagnostic imaging of skeletal muscles.
引用
收藏
页数:12
相关论文
共 50 条
  • [31] New radiopharmaceuticals for cancer imaging and biological characterization using PET
    Fukuda, H
    Furumoto, S
    Iwata, R
    Kubota, K
    PET AND MOLECULAR IMAGING: STATE OF THE ART AND FUTURE PERSPECTIVES, 2004, 1264 : 158 - 165
  • [32] Clinical values of FDG PET in polymyositis and dermatomyositis syndromes: imaging of skeletal muscle inflammation
    Tateyama, Maki
    Fujihara, Kazuo
    Misu, Tatsuro
    Arai, Akira
    Kaneta, Tomohiro
    Aoki, Masashi
    BMJ OPEN, 2015, 5 (01):
  • [33] Co-registered PET-CT imaging of symmetrical skeletal muscle uptake: It is not within the muscle.
    Hany, TF
    Gharehpapagh, E
    Stumpe, KD
    von Schulthess, G
    JOURNAL OF NUCLEAR MEDICINE, 2002, 43 (05) : 38P - 38P
  • [34] Imaging of the skeletal muscle metastases
    Arpaci, T.
    Ugurluer, G.
    Akbas, T.
    Arpaci, R. B.
    Serin, M.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2012, 16 (15) : 2057 - 2063
  • [35] REGULATION OF PET RADIOPHARMACEUTICALS
    TILYOU, SM
    JOURNAL OF NUCLEAR MEDICINE, 1991, 32 (04) : N34 - N34
  • [36] Radiopharmaceuticals for PET studies
    Langstrom, B
    Bergstrom, M
    Hartvig, P
    Sundin, A
    Takola, R
    Valind, S
    Torstenson, R
    Antoni, G
    Bjurling, P
    Fasth, KJ
    Westerberg, G
    Andersson, Y
    Kihlberg, T
    Jacobson, G
    Ogren, M
    Neu, H
    Watanabe, Y
    TOMOGRAPHY IN NUCLEAR MEDICINE, 1996, : 359 - 376
  • [37] Copper and diphosphine complexes:: new radiopharmaceuticals for PET imaging of the myocardium.
    Panichelli, P.
    Castignani, L.
    Colonna, M.
    Martini, D.
    Valentini, G.
    Bramucci, M.
    Nasuti, C.
    Ninona, L.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2007, 34 : S170 - S170
  • [38] Synthesis of radiopharmaceuticals and applications in functional positron emission tomography (PET) imaging
    Scott, Peter
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 249
  • [39] Will the new PET radiopharmaceuticals overtake Myocardial Perfusion Imaging in the diagnosis of CAD?
    Moreira, R. F. S.
    Queiroz, A. I. P.
    Paixao, G.
    Soares, C.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2017, 44 : S877 - S877
  • [40] Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade
    Crisan, George
    Moldovean-Cioroianu, Nastasia Sanda
    Timaru, Diana-Gabriela
    Andries, Gabriel
    Cainap, Calin
    Chis, Vasile
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (09)