New Meroterpenoids and α-Pyrone Derivatives Isolated from the Mangrove Endophytic Fungal Strain Aspergillus sp. GXNU-Y85

被引：0
|
作者：
Wang, Chungu [1 ]
Wang, Fanfan [2 ]
Tao, Pingfang [2 ]
Shao, Yuanling [1 ]
Li, Qing [1 ]
Gu, Minmin [1 ]
Liao, Zhixin [1 ]
Qin, Feng [2 ]
机构：
[1] Southeast Univ, Sch Chem & Chem Engn, Dept Pharmaceut Engn, Nanjing 211189, Peoples R China
[2] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, Yulin 537000, Peoples R China
来源：
MARINE DRUGS | 2024年 / 22卷 / 06期
关键词：
Aspergillus sp; meroterpenoids; alpha-pyrone derivatives; anti-proliferation activity; METABOLITES;
D O I：
10.3390/md22060277
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new meroterpenoids, aspergienynes O and P (1 and 2), one new natural compound, aspergienyne Q (3), and a new alpha-pyrone derivative named 3-(4-methoxy-2-oxo-2H-pyran-6-yl)butanoic acid (4) were isolated from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y85, along with five known compounds (5-9). The absolute configurations of those new isolates were confirmed through extensive analysis using spectroscopic data (HRESIMS, NMR, and ECD). The pharmacological study of the anti-proliferation activity indicated that isolates 5 and 9 displayed moderate inhibitory effects against HeLa and A549 cells, with the IC50 values ranging from 16.6 to 45.4 mu M.
引用
收藏
页数：9
相关论文
共 50 条
  • [21] α-pyrone derivatives from the endophytic Fusarium sp. L33 isolated from Dioscorea opposita
    Tian, Ruo-Dan
    Sheng, Meng-Ke
    Zhao, Ying-Fei
    Wen, Chun-Nan
    Liu, Miao
    Ma, Ji
    PHYTOCHEMISTRY LETTERS, 2024, 62 : 14 - 17
  • [22] Three New Resveratrol Derivatives from the Mangrove Endophytic Fungus Alternaria sp.
    Wang, Jinhua
    Cox, Daniel G.
    Ding, Weijia
    Huang, Guanghao
    Lin, Yongcheng
    Li, Chunyuan
    MARINE DRUGS, 2014, 12 (05): : 2840 - 2850
  • [23] New α-Pyrone derivatives from the endophytic fungus Embellisia sp
    Ahmed M. Metwaly
    Amira S. Wanas
    Mohamed M. Radwan
    Samir A. Ross
    Mahmoud A. ElSohly
    Medicinal Chemistry Research, 2017, 26 : 1796 - 1800
  • [24] New α-Pyrone derivatives from the endophytic fungus Embellisia sp
    Metwaly, Ahmed M.
    Wanas, Amira S.
    Radwan, Mohamed M.
    Ross, Samir A.
    ElSohly, Mahmoud A.
    MEDICINAL CHEMISTRY RESEARCH, 2017, 26 (08) : 1796 - 1800
  • [25] Asperterpenols A and B, New Sesterterpenoids Isolated from a Mangrove Endophytic Fungus Aspergillus sp 085242
    Xiao, Ze'en
    Huang, Huarong
    Shao, Changlun
    Xia, Xuekui
    Ma, Lin
    Huang, Xishan
    Lu, Yongjun
    Lin, Yongcheng
    Long, Yuhua
    She, Zhigang
    ORGANIC LETTERS, 2013, 15 (10) : 2522 - 2525
  • [26] A new anthraquinone from mangrove endophytic fungus Aspergillus sp. 16-5C
    Xiao, Ze'en
    Lin, Shao'e
    She, Zhigang
    Lu, Yongjun
    Tan, Zhen
    Liu, Yonghong
    NATURAL PRODUCT RESEARCH, 2023, 37 (08) : 1271 - 1276
  • [27] New Benzofuranoids and Phenylpropanoids from the Mangrove Endophytic Fungus, Aspergillus sp. ZJ-68
    Cai, Runlin
    Jiang, Hongming
    Zang, Zhenming
    Li, Chunyuan
    She, Zhigang
    MARINE DRUGS, 2019, 17 (08)
  • [28] Two new pyrone derivatives from the mangrove-derived endophytic fungus Aspergillus sydowii #2B
    Wang, Yuhui
    Zhong, Zhiwei
    Zhao, Fei
    Zheng, Junxia
    Zheng, Xi
    Zhang, Kun
    Huang, Huarong
    NATURAL PRODUCT RESEARCH, 2022, 36 (15) : 3872 - 3878
  • [29] α-pyrone derivatives from endophytic fungus Diaporthe sp. RJ-41
    Zhang, Qiong
    Ma, Wei-guang
    Zhao, Qing
    Zhao, Yu-ying
    Huang, Zhi-pu
    Xu, Yu-xiao
    Zhu, De-fen
    Li, Jin-cun
    Zhang, Xiao-mei
    BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2021, 94
  • [30] A new sesquiterpene from endophytic fungus Aspergillus sp.
    Luo, Shao-Liu
    Li, Guo-Hong
    Liu, Fang-Fang
    Lei, Li-Ping
    Xia, Zhen-Yuan
    Zhang, Ke-Qin
    NATURAL PRODUCT RESEARCH, 2012, 26 (14) : 1334 - 1338
12345