Management of ALL in adults: 2024 ELN recommendations from a European expert panel

被引：26

作者：

Goekbuget, Nicola ^{[1
]}

Boissel, Nicolas ^{[2
]}

Chiaretti, Sabina ^{[3
]}

Dombret, Herve ^{[4
]}

Doubek, Michael ^{[5
]}

Fielding, Adele ^{[6
]}

Foa, Robin

Giebel, Sebastian ^{[7
]}

Hoelzer, Dieter ^{[1
]}

Hunault, Mathilde ^{[8
]}

Marks, David I. ^{[9
]}

Martinelli, Giovanni ^{[10
]}

Ottmann, Oliver ^{[11
]}

Rijneveld, Anita ^{[12
]}

Rousselot, Philippe ^{[13
]}

Ribera, Josep ^{[14
]}

Bassan, Renato ^{[15
]}

机构：

[1] Goethe Univ, Univ Hosp, Dept Med 2, Hematol Oncol, Frankfurt, Germany

[2] Hosp St Louis, AP HP, Paris, France

[3] Sapienza Univ, Dept Translat & Precis Med, Hematol, Rome, Italy

[4] Univ Paris Cite, Univ Hosp St Louis, AP HP, St Louis Res Inst,Leukemia Dept, Paris, France

[5] Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno, Czech Republic

[6] UCL Canc Inst, London, England

[7] Mar Sklodowska Curie Natl Res Inst Oncol, Dept Bone Marrow Transplantat & Onco Hematol, Gliwice Branch, Gliwice, Poland

[8] Malad Sang Univ Hosp Angers, Natl Ctr Sci Res, FHU Goal, INSERM, Angers, France

[9] Univ Hosp Bristol NHS Fdn Trust, Bristol, Avon, England

[10] IRCCS Ist Romagnolo Studio Tumori Dino Amadori, Meldola, Italy

[11] Cardiff Univ, Sch Med, Div Canc & Genet, Cardiff, Wales

[12] Erasmus MC Canc Inst, Rotterdam, Netherlands

[13] Univ Paris Saclay, Ctr Hosp Versailles, Dept Clin Hematol, Versailles, France

[14] Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Josep Carreras Res Inst, Dept Clin Hematol, Badalona, Spain

[15] Osped Angelo, Div Hematol, Mestre Venice, Italy

来源：

BLOOD | 2024年 / 143卷 / 19期

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; STEM-CELL TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; TERM-FOLLOW-UP; TOTAL-BODY IRRADIATION; TYROSINE KINASE INHIBITORS; CHIMERIC ANTIGEN RECEPTOR; COLONY-STIMULATING FACTOR; CHEMOTHERAPY PLUS DASATINIB; LOW-INTENSITY CHEMOTHERAPY;

D O I：

10.1182/blood.2023023568

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Experts from the European Leukemia Net (ELN) working group for adult acute lymphoblastic leukemia have identifi ed an unmet need for guidance regarding management of adult acute lymphoblastic leukemia (ALL) from diagnosis to aftercare. The group has previously summarized their recommendations regarding diagnostic approaches, prognostic factors, and assessment of ALL. The current recommendation summarizes clinical management. It covers treatment approaches, including the use of new immunotherapies, application of minimal residual disease for treatment decisions, management of speci fi c subgroups, and challenging treatment situations as well as late effects and supportive care. The recommendation provides guidance for physicians caring for adult patients with ALL which has to be complemented by regional expertise preferably provided by national academic study groups.

引用

页码：1903 / 1930

页数：28

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