Kidney Aging and Chronic Kidney Disease

被引:2
|
作者
Zhang, Yingying [1 ,2 ]
Yu, Chen [3 ]
Li, Xiaogang [1 ,2 ]
机构
[1] Mayo Clin, Dept Internal Med, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
[3] Tongji Univ, Shanghai Tongji Hosp, Dept Nephrol, Sch Med, Shanghai 200092, Peoples R China
关键词
kidney aging; chronic kidney disease; cell senescence; TUBULAR EPITHELIAL-CELLS; CELLULAR SENESCENCE; CALORIE RESTRICTION; MITOCHONDRIAL DYSFUNCTION; RENAL INFLAMMATION; FUNCTIONAL-CHANGES; UP-REGULATION; AUTOPHAGY; FIBROSIS; EXPRESSION;
D O I
10.3390/ijms25126585
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The process of aging inevitably leads to an increase in age-related comorbidities, including chronic kidney disease (CKD). In many aspects, CKD can be considered a state of accelerated and premature aging. Aging kidney and CKD have numerous common characteristic features, ranging from pathological presentation and clinical manifestation to underlying mechanisms. The shared mechanisms underlying the process of kidney aging and the development of CKD include the increase in cellular senescence, the decrease in autophagy, mitochondrial dysfunction, and the alterations of epigenetic regulation, suggesting the existence of potential therapeutic targets that are applicable to both conditions. In this review, we provide a comprehensive overview of the common characteristics between aging kidney and CKD, encompassing morphological changes, functional alterations, and recent advancements in understanding the underlying mechanisms. Moreover, we discuss potential therapeutic strategies for targeting senescent cells in both the aging process and CKD.
引用
收藏
页数:28
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