Lewis base-catalyzed [3+2] annulation of β-oxo-acrylamides with acyl isothiocyanates: facile access to 2-iminothiazolidin-4-one derivatives

被引：2

作者：

Liu, Wanxing ^{[1
]}

Mao, Zhehui ^{[3
]}

Chong, Daohuang ^{[3
]}

Wang, Zhaoxue ^{[2
]}

Zhang, Keying ^{[2
]}

Wu, Lingang ^{[2
,3
]}

Xie, Lei ^{[2
]}

机构：

[1] Nonpubl Enterprise Serv Ctr Liaocheng, Liaocheng 252000, Shandong, Peoples R China

[2] Liaocheng Univ, Sch Chem & Chem Engn, Sch Pharm, Liaocheng 252000, Shandong, Peoples R China

[3] Jinan Enlighten Biotechnol Co Ltd, Jinan 250013, Shandong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2024年 / 140卷

关键词：

Acyl isothiocyanate; 3+2] annulation; 2-Iminothiazolidin-4-one; Oxo-acrylamide; SELECTIVE-INHIBITION; AZAOXYALLYL CATIONS; CYCLOADDITION; SULFUR; 5-ARYLIDENE-2-IMINO-4-THIAZOLIDINONES; DESIGN; OXYGEN;

D O I：

10.1016/j.tetlet.2024.155022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient protocol for the Cs 2 CO 3 -catalyzed [3 + 2] annulation of /3-oxo-acrylamides with acyl isothiocyanates has been developed under mild reaction conditions. This strategy offers a streamlined route to access 2-iminothiazolidin-4-one derivatives with yields of 53 -83 %. The annulation is characterized by being transition-metal-free, atom-economic, and operationally straightforward.

引用

页数：4

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