Polymorphism of CYP3A4*18 is associated with anti-tuberculosis drug-induced hepatotoxicity

被引：0
|
作者：
Lee, Shih-Wei [1 ,2 ]
Chen, Pei-Tzu [3 ]
Liu, Chi-Wei [4 ]
Li, Yuan-Hsu [5 ]
Wu, Lawrence Shih-Hsin [3 ]
机构：
[1] Taoyuan Gen Hosp, Dept Chest Med, Dept Hlth & Welf, Taoyuan 33004, Taiwan
[2] Yuanpei Univ Med Technol, Dept Nursing, Hsinchu 30015, Taiwan
[3] China Med Univ, Grad Inst Biomed Sci, Taichung 404328, Taiwan
[4] Taoyuan Gen Hosp, Translat Med Ctr, Dept Hlth & Welf, Taoyuan 33004, Taiwan
[5] Taoyuan Gen Hosp, Dept Lab Med, Dept Hlth & Welf, Taoyuan 33004, Taiwan
来源：
PHARMACOGENOMICS | 2024年 / 25卷 / 5-6期
关键词：
anti-tuberculosis drugs; cytochrome P450 genes; hepatotoxicity; LIVER-INJURY; GENETIC POLYMORPHISMS; CYTOCHROME-P450; EXPRESSION; RIFAMPIN; PHARMACOKINETICS; PYRAZINAMIDE; HEPATITIS; VARIANTS; CYP3A4;
D O I：
10.1080/14622416.2024.2346069
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: The association between cytochrome P450 (CYP) gene polymorphisms and anti-tuberculosis drug-induced hepatotoxicity (ATDH) was investigated in patients with or without pre-existing liver diseases (PLD). Materials & methods: We followed 164 tuberculosis subjects, 58 with PLD and 106 without PLD. Polymorphisms in CYP2D6, CYP2C9, CYP2C19, CYP3A4 and CYP3A5 were analyzed using the TaqMan (R) SNP genotyping assay. Results: The CYP3A4*18 heterozygous genotype was associated with ATDH (OR: 3.24, 95% CI: 1.06-9.86) regardless of PLD presence. Among subjects without PLD, CYP3A4*18 heterozygotes had significantly higher ATDH risk (OR: 9.10, 95% CI: 1.56-53.16). Conversely, in the PLD group, CYP3A4*18 heterozygotes had lower ATDH risk (OR: 0.21, 95% CI: 0.05-0.98). Conclusion: CYP3A4*18 genotype is linked to ATDH in tuberculosis patients, with differential effects based on PLD presence.
引用
收藏
页码：241 / 247
页数：7
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