Smoking Intensity is Associated With Progressive Optic Nerve Head Vessel Density Loss in Glaucoma

被引:0
|
作者
Nishida, Takashi [1 ]
Weinreb, Robert N. [1 ]
Tansuebchueasai, Natchada [1 ,2 ]
Wu, Jo-Hsuan [1 ]
Meller, Leo [1 ]
Mahmoudinezhad, Golnoush [1 ]
Gunasegaran, Gopikasree [1 ]
Adelpour, Mohsen [1 ]
Moghimi, Sasan [1 ,3 ]
机构
[1] Univ Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Viterbi Family Dept Ophthalmol, La Jolla, CA 92093 USA
[2] Prince Songkla Univ, Fac Med, Dept Ophthalmol, Hat Yai, Songkhla, Thailand
[3] Univ Calif San Diego, Shiley Eye Inst, 9500 Campus Point Dr, La Jolla, CA 92093 USA
基金
美国国家卫生研究院;
关键词
Smoking; optical coherence tomography angiography; glaucoma; progression; OPEN-ANGLE GLAUCOMA; LIFE-STYLE; CIGARETTE-SMOKING; BLOOD-FLOW; OCULAR HYPERTENSION; AFRICAN DESCENT; RISK-FACTORS; PREVALENCE; PERFUSION;
D O I
10.1097/IJG.0000000000002410
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Pr & eacute;cis: A lifetime history of greater smoking consumption was associated with faster vessel density loss over time. Smoking intensity should be considered when assessing the risk of glaucoma progression, as well as its management. Purpose: To investigate the relationship of smoking and smoking intensity, with the rate of optic nerve head (ONH) whole image capillary density (wiCD) loss in primary open angle glaucoma (POAG) and glaucoma suspect patients. Methods: In this longitudinal study, patients with POAG who had at least 2 years of follow-up and optical coherence tomography angiography (OCTA) performed at a minimum of 4 visits were selected for study. The smoking intensity was calculated as the pack-year at the baseline OCTA. Univariable and multivariable linear mixed models were used to determine the effect of each parameter on the rates of wiCD loss over time. Nonlinear least-squares estimation with piecewise regression model was used to investigate the cutoff point for the relationship between wiCD loss and smoking intensity. Results: One hundred sixty-four eyes (69 glaucoma suspect and 95 POAG) of 110 patients were included with a mean (95% CI) follow-up of 4.0 (3.9 to 4.1) years. Of the 110 patients, 50 (45.5%) had a reported history of smoking. Greater smoking intensity was associated with faster wiCD loss [-0.11 (-0.23 to 0.00)] %/year per 10 pack-year higher; P=0.048) after adjusting for covariates. The wiCD thinning became significantly faster when smoking intensity was greater than 22.2 pack-years. Smoking had no effect on the rate of wiCD thinning in patients who smoked <22.2 pack-years during their lifetime. Conclusions: A history of greater smoking consumption was associated with faster vessel density loss, suggesting smoking intensity as a potential risk factor for glaucoma.
引用
收藏
页码:394 / 399
页数:6
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