Imaging chronic active lesions in multiple sclerosis: a consensus statement

被引:39
|
作者
Bagnato, Francesca [1 ,2 ]
Sati, Pascal [3 ]
Hemond, Christopher C. [4 ]
Elliott, Colm [5 ]
Gauthier, Susan A. [6 ]
Harrison, Daniel M. [7 ,8 ]
Mainero, Caterina [9 ]
Oh, Jiwon [10 ]
Pitt, David [11 ]
Shinohara, Russell T. [12 ,13 ]
Smith, Seth A. [14 ]
Trapp, Bruce [15 ]
Azevedo, Christina J. [16 ]
Calabresi, Peter A. [17 ]
Henry, Roland G. [18 ]
Laule, Cornelia [19 ,20 ,21 ,22 ]
Ontaneda, Daniel [23 ]
Rooney, William D. [24 ]
Sicotte, Nancy L. [25 ]
Reich, Daniel S. [26 ]
Absinta, Martina [17 ,27 ,28 ]
机构
[1] Vanderbilt Univ, Dept Neurol, Neuroimmunol Div, Neuroimaging Unit,Med Ctr, 2201 Childrens Way,Suite 1222, Nashville, TN 37212 USA
[2] Tennessee Valley Healthcare Syst, Nashville VA Med Ctr, Dept Neurol, Nashville, TN 37212 USA
[3] Cedars Sinai Med Ctr, Dept Neurol, Neuroimaging Program, Los Angeles, CA 90048 USA
[4] Univ Massachusetts, Dept Neurol, Chan Med Sch, Worcester, MA 01655 USA
[5] NeuroRx Res, Montreal, PQ H2X 3P9, Canada
[6] Weill Cornell Med, Dept Neurol, New York, NY 10021 USA
[7] Univ Maryland, Dept Neurol, Sch Med, Baltimore, MD 21201 USA
[8] VA Maryland Healthcare Syst, Baltimore VA Med Ctr, Dept Neurol, Baltimore, MD 21201 USA
[9] Harvard Med Sch, Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Dept Radiol, Boston, MA 02115 USA
[10] Univ Toronto, St Michaels Hosp, Div Neurol, Toronto M5S, ON, Canada
[11] Yale Sch Med, Dept Neurol, New Haven, CT 06510 USA
[12] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Penn Stat Imaging & Visualizat Endeavor, Philadelphia, PA 19104 USA
[13] Univ Penn, Ctr Biomed Image Comp & Analyt, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA
[14] Vanderbilt Univ, Inst Imaging Sci, Dept Radiol & Radiol Sci, Med Ctr, Nashville, TN 37235 USA
[15] Cleveland Clin, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44195 USA
[16] Univ Southern Calif, Dept Neurol, Keck Sch Med, Los Angeles, CA 90007 USA
[17] Johns Hopkins Univ, Dept Neurol & Neurosci, Sch Med, Baltimore, MD 21205 USA
[18] Univ Calif San Francisco, Weill Inst Neurosci, Dept Neurol, San Francisco, CA 94158 USA
[19] Univ British Columbia, Dept Radiol, Vancouver, BC V6T 1Z4, Canada
[20] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V6T 1Z4, Canada
[21] Univ British Columbia, Dept Phys & Astron, Vancouver, BC V6T 1Z4, Canada
[22] Univ British Columbia, Int Collaborat Repair Discoveries ICORD, Vancouver, BC V6T 1Z4, Canada
[23] Cleveland Clin, Mellen Ctr Multiple Sclerosis, Cleveland, OH 44195 USA
[24] Oregon Hlth & Sci Univ, Adv Imaging Res Ctr, Portland, OR 97239 USA
[25] Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA 90048 USA
[26] Natl Inst Neurol Disorders & Stroke, NIH, Translat Neuroradiol Sect, Bethesda, MD 20892 USA
[27] Univ Vita Salute San Raffaele, Inst Expt Neurol, Div Neurosci, Translat Neuropathol Unit, I-20132 Milan, Italy
[28] IRCCS San Raffaele Sci Inst, I-20132 Milan, Italy
基金
美国国家卫生研究院; 加拿大自然科学与工程研究理事会;
关键词
chronic active lesions; iron; microglia; multiple sclerosis; paramagnetic rim lesions; MRI-defined slowly evolving lesions; SUSCEPTIBILITY MAPPING QSM; ENABLED DIPOLE INVERSION; WHITE-MATTER LESIONS; IRON RIM LESIONS; MICROGLIAL ACTIVATION; BLACK-HOLES; IN-VIVO; TRANSLOCATOR PROTEIN; ENHANCING LESIONS; ZERO REFERENCE;
D O I
10.1093/brain/awae013
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Chronic active lesions (CAL) are an important manifestation of chronic inflammation in multiple sclerosis and have implications for non-relapsing biological progression. In recent years, the discovery of innovative MRI and PET-derived biomarkers has made it possible to detect CAL, and to some extent quantify them, in the brain of persons with multiple sclerosis, in vivo.Paramagnetic rim lesions on susceptibility-sensitive MRI sequences, MRI-defined slowly expanding lesions on T1-weighted and T2-weighted scans, and 18-kDa translocator protein-positive lesions on PET are promising candidate biomarkers of CAL. While partially overlapping, these biomarkers do not have equivalent sensitivity and specificity to histopathological CAL. Standardization in the use of available imaging measures for CAL identification, quantification and monitoring is lacking.To fast-forward clinical translation of CAL, the North American Imaging in Multiple Sclerosis Cooperative developed a consensus statement, which provides guidance for the radiological definition and measurement of CAL. The proposed manuscript presents this consensus statement, summarizes the multistep process leading to it, and identifies the remaining major gaps in knowledge. On behalf of the North American Imaging in Multiple Sclerosis (NAIMS) Cooperative, Bagnato et al. present a consensus statement which provides guidance for the radiological definition and measurement of chronic active lesions in people with multiple sclerosis, and which identifies remaining gaps in knowledge.
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页数:21
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