Revitalizing the Gut Microbiome in Chronic Kidney Disease: A Comprehensive Exploration of the Therapeutic Potential of Physical Activity

被引：1

作者：

Vandecruys, Marieke ^{[1
]}

De Smet, Stefan ^{[2
]}

De Beir, Jasmine ^{[3
]}

Renier, Marie ^{[4
]}

Leunis, Sofie ^{[5
]}

Van Criekinge, Hanne ^{[5
]}

Glorieux, Griet ^{[6
]}

Raes, Jeroen ^{[7
,8
]}

Wyngaert, Karsten Vanden ^{[6
]}

Nagler, Evi ^{[6
]}

Calders, Patrick ^{[3
]}

Monbaliu, Diethard ^{[5
,9
]}

Cornelissen, Veronique ^{[4
]}

Evenepoel, Pieter ^{[1
,10
]}

Van Craenenbroeck, Amaryllis H. ^{[1
,10
]}

机构：

[1] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Nephrol & Renal Transplantat Res Grp, B-3000 Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Movement Sci, Exercise Physiol Res Grp, B-3000 Leuven, Belgium

[3] Univ Ghent, Dept Rehabil Sci, B-9000 Ghent, Belgium

[4] Katholieke Univ Leuven, Dept Rehabil Sci, Grp Rehabil Internal Disorders, B-3000 Leuven, Belgium

[5] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Abdominal Transplantat, B-3000 Leuven, Belgium

[6] Ghent Univ Hosp, Dept Internal Med & Pediat, Nephrol Sect, B-9000 Ghent, Belgium

[7] Rega Inst Med Res, Dept Microbiol & Immunol, B-3000 Leuven, Belgium

[8] Katholieke Univ Leuven, VIB Ctr Microbiol, B-3000 Leuven, Belgium

[9] Transplantoux Fdn, B-3000 Leuven, Belgium

[10] Univ Hosp Leuven, Dept Nephrol, B-3000 Leuven, Belgium

来源：

TOXINS | 2024年 / 16卷 / 06期

关键词：

chronic kidney disease; gut microbiome; physical activity; exercise; TOLL-LIKE RECEPTOR; INTESTINAL ALKALINE-PHOSPHATASE; IMPAIRS BARRIER FUNCTION; CHRONIC-RENAL-FAILURE; MODERATE EXERCISE; GASTROINTESTINAL TRANSIT; CARDIOVASCULAR-DISEASE; BUTYRATE CONCENTRATION; SYSTEMIC INFLAMMATION; UREMIC TOXINS;

D O I：

10.3390/toxins16060242

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Both physical inactivity and disruptions in the gut microbiome appear to be prevalent in patients with chronic kidney disease (CKD). Engaging in physical activity could present a novel nonpharmacological strategy for enhancing the gut microbiome and mitigating the adverse effects associated with microbial dysbiosis in individuals with CKD. This narrative review explores the underlying mechanisms through which physical activity may favorably modulate microbial health, either through direct impact on the gut or through interorgan crosstalk. Also, the development of microbial dysbiosis and its interplay with physical inactivity in patients with CKD are discussed. Mechanisms and interventions through which physical activity may restore gut homeostasis in individuals with CKD are explored.

引用

页数：28

共 50 条

[31] Gut microbiome-dependent systemic alterations in experimental chronic kidney disease
Yarritu, Alex
Anders, Wibke
Thiele, Arne
Holle, Johannes Benjamin
Szijarto, Istvan Andras
Rauch, Ariana
Bartolomaeus, Hendrik
Wilck, Nicola
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2024, 39
[32] Gut microbiome-dependent systemic alterations in experimental chronic kidney disease
Yarritu, Alex
Anders, Wibke
Thiele, Arne
Holle, Johannes Benjamin
Szijarto, Istvan Andras
Rauch, Ariana
Bartolomaeus, Hendrik
Wilck, Nicola
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2024, 39 : I894 - I894
[33] Interconnections between the Gut Microbiome and Alzheimer's Disease: Mechanisms and Therapeutic Potential
Sait, Ahmad M.
Day, Philip J. R.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (16)
[34] Gut microbiota and probiotics intervention: A potential therapeutic target for management of cardiometabolic disorders and chronic kidney disease?
Cavalcanti Neto, Marinaldo Pacifico
Aquino, Jailane de Souza
Romao da Silva, Larissa de Fatima
Silva, Ruanniere de Oliveira
de Lima Guimaraes, Keyth Sulamitta
de Oliveira, Yohanna
de Souza, Evandro Leite
Magnani, Marciane
Vidal, Hubert
de Brito Alves, Jose Luiz
PHARMACOLOGICAL RESEARCH, 2018, 130 : 152 - 163
[35] Gut Dysbiosis and Probiotic Therapy in Chronic Kidney Disease: A Comprehensive Review
Ribeiro, Fernanda Priscila Barbosa
Freire, Micaelle Oliveira de Luna
Coutinho, Daniella de Oliveira
Cirilo, Marry Aneyts de Santana
Alves, Jose Luiz de Brito
PROBIOTICS AND ANTIMICROBIAL PROTEINS, 2024,
[36] The Role of the Gut Microbiome in Kidney Stone Disease
Hanstock, Sarah
Chew, Ben
Lange, Dirk
UROLOGIC CLINICS OF NORTH AMERICA, 2024, 51 (04) : 475 - 482
[37] Gut microbiome is unique in kidney stone disease
Rebecca Kelsey
Nature Reviews Urology, 2016, 13 (7) : 368 - 368
[38] The Gut Microbiome, Kidney Disease, and Targeted Interventions
Ramezani, Ali
Raj, Dominic S.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, 25 (04): : 657 - 670
[39] Gut microbiome and kidney disease: a bidirectional relationship
Souhaila Al Khodor
Ibrahim F. Shatat
Pediatric Nephrology, 2017, 32 : 921 - 931
[40] Gut microbiome and kidney disease: a bidirectional relationship
Al Khodor, Souhaila
Shatat, Ibrahim F.
PEDIATRIC NEPHROLOGY, 2017, 32 (06) : 921 - 931

← 1 2 3 4 5 →