Because the traditional evaluation methods have the problems of low weight calculation accuracy and high evaluation error rate, a comprehensive evaluation method of network teaching quality in colleges and universities based on entropy weight TOPSIS model is proposed. Firstly, questionnaire survey, expert interview and statistical methods are used to obtain the data related to network teaching. Secondly, the evaluation index system is established according to relevant principles. Finally, the entropy weight method is used to determine the weight of the evaluation index, and combined with the calculation results of the weight of index, the TOPSIS model is used to get the relevant evaluation results. The experimental results show that this method can realise the evaluation of network teaching quality in colleges and universities. The average accuracy of evaluation index weight calculation is 95.9%, and the average evaluation error rate is 7.6%.