Cu(II)-Catalyzed Hydroboration Reactions of 1,1-Disubstituted α,β-Unsaturated Ketones, Esters, and Amides in Pure Water

被引：1

作者：

Zhao, Xue ^{[1
]}

Li, Weishuang ^{[1
]}

Zhou, Lijie ^{[1
]}

Zhao, Xuhong ^{[1
,2
]}

Zhang, Yaoyao ^{[1
]}

Li, Bojie ^{[1
]}

Li, Rong ^{[2
]}

Zhu, Lei ^{[1
,2
]}

机构：

[1] Hubei Engn Univ, Sch Chem & Mat Sci, Hubei Key Lab Qual Control Characterist Fruits & V, Xiaogan 432000, Peoples R China

[2] Hubei Univ, Sch Mat Sci & Engn, Minist Educ Key Lab Green Preparat & Applicat Func, Wuhan 430062, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 12期

基金：

中国国家自然科学基金;

关键词：

CATALYZED BETA-BORATION; ARYL-BORONIC ACIDS; CARBONYL-COMPOUNDS; ROOM-TEMPERATURE; ASYMMETRIC-SYNTHESIS; ARYLBORONIC ACIDS; N-ARYLATION; BORYLATION; BIS(PINACOLATO)DIBORON; NANOPARTICLES;

D O I：

10.1021/acs.joc.3c02942

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here, a Cu-2(OH)(2)CO3-catalyzed hydroboration reaction of 1,1-disubstituted alpha,beta-unsaturated compounds has been developed. The reaction was carried out using water as a solvent at room temperature except for N-monosubstituted alpha,beta-unsaturated amides. This method is applicable to diverse 1,1-disubstituted alpha,beta-unsaturated ketones, esters, and amides, showing excellent reactivity (up to 98% yield). Gram-scale experiments and functional group transformations further demonstrated the practicality of this method.

引用

页码：8334 / 8341

页数：8

共 30 条

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