S-Equol Ameliorates Menopausal Osteoarthritis in Rats through Reducing Oxidative Stress and Cartilage Degradation

被引:1
|
作者
Hu, Yu-Chen [1 ,2 ]
Huang, Tzu-Ching [1 ,2 ]
Huang, Li-Wen [3 ]
Cheng, Hsiao-Ling [4 ]
Hsieh, Bau-Shan [1 ,2 ]
Chang, Kee-Lung [1 ,2 ]
机构
[1] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Biochem, Kaohsiung 807378, Taiwan
[2] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 807378, Taiwan
[3] Kaohsiung Med Univ, Coll Hlth Sci, Dept Med Lab Sci & Biotechnol, Kaohsiung 807378, Taiwan
[4] Kaohsiung Municipal Minsheng Hosp, Dept Pharm, Kaohsiung 802511, Taiwan
关键词
S-equol; isoflavones; osteoarthritis; degenerative joint disease; menopause; II COLLAGEN DEGRADATION; KNEE OSTEOARTHRITIS; SUBCHONDRAL BONE; OVARIECTOMIZED RATS; METABOLIC SYNDROME; RISK-FACTORS; POSTMENOPAUSAL WOMEN; HAND OSTEOARTHRITIS; ARTICULAR-CARTILAGE; ESTROGEN THERAPY;
D O I
10.3390/nu16142364
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Osteoarthritis (OA) is a chronic degenerative disease leading to articular cartilage destruction. Menopausal and postmenopausal women are susceptible to both OA and osteoporosis. S-equol, a soy isoflavone-derived molecule, is known to reduce osteoporosis in estrogen-deficient mice, but its role in OA remains unknown. This study aimed to explore the effect of S-equol on different degrees of menopausal OA in female Sprague-Dawley (SD) rats induced by estrogen deficiency caused by bilateral ovariectomy (OVX) combined with intra-articular injection of mono-iodoacetate (MIA). Knee joint histopathological change; serum biomarkers of bone turnover, including N-terminal propeptide of type I procollagen (PINP), C-terminal telopeptide of type I collagen (CTX-I) and N-terminal telopeptide of type I collagen (NTX-I); the cartilage degradation biomarkers hyaluronic acid (HA) and N-terminal propeptide of type II procollagen (PIINP); and the matrix-degrading enzymes matrix metalloproteinases (MMP)-1, MMP-3 and MMP-13, as well as the oxidative stress-inducing molecules nitric oxide (NO) and hydrogen peroxide (H2O2), were assessed for evaluation of OA progression after S-equol supplementation for 8 weeks. The results showed that OVX without or with MIA injection induced various severity levels of menopausal OA by increasing pathological damage, oxidative stress, and cartilage matrix degradation to various degrees. Moreover, S-equol supplementation could significantly reduce these increased biomarkers in different severity levels of OA. This indicates that S-equol can lessen menopausal OA progression by reducing oxidative stress and the matrix-degrading enzymes involved in cartilage degradation.
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页数:14
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