Afamelanotide in protoporphyria and other skin diseases: a review

被引：1

作者：

Polanska, Adriana ^{[1
,3
]}

Wegner, Joanna ^{[2
]}

Nutbohm, Paula ^{[2
]}

Staubach, Petra ^{[2
]}

Zaba, Ryszard ^{[1
]}

Danczak-Pazdrowska, Aleksandra ^{[1
]}

Jenerowicz, Dorota ^{[1
]}

机构：

[1] Poznan Univ Med Sci, Dept Dermatol, Poznan, Poland

[2] Univ Med Ctr Mainz, Dept Dermatol, Mainz, Germany

[3] Univ Med Sci, Dept Dermatol, 49 Przybyszewskiego St, PL-60355 Poznan, Poland

来源：

POSTEPY DERMATOLOGII I ALERGOLOGII | 2024年 / 41卷 / 02期

关键词：

afamelanotide; protoporphyria; erythropoietic porphyria; MELANOCYTE-STIMULATING HORMONE; ULTRAVIOLET-B PHOTOTHERAPY; ERYTHROPOIETIC PROTOPORPHYRIA; ALPHA-MELANOTROPIN; GENE VARIANTS; BETA-CAROTENE; ANALOG; PIGMENTATION; VITILIGO; EFFICACY;

D O I：

10.5114/ada.2024.138818

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Afamelanotide is a synthetic alpha melanocyte stimulating hormone presenting a higher activity than natural hormones. Its main properties are related to the enhanced production of eumelanin by agonistically binding to the melanocortin-1 receptor. Since 2016 afamelanotide has been especially applied to treat cases of erythropoietic porphyria (EPP), where painful photosensitivity has been observed since early childhood. The positive effect of af - amelanotide in EPP administered subcutaneously improved tolerance to artificial white light and increased pain -free time spent in direct sunlight. In this review we summarize the possible use of afamelanotide in dermatology, with special emphasis on EPP and encourage including afamelanotide as a treatment option in patient care.

引用

页码：149 / 154

页数：6

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