Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by 'click' chemistry and investigation of their biological activity

被引：4

作者：

Reddy, P. Venkat ^{[1
]}

Saquib, Mohammad ^{[1
]}

Mishra, Nripendra N. ^{[2
]}

Shukla, Praveen K. ^{[2
]}

Shaw, Arun K. ^{[1
]}

机构：

[1] Cent Drug Res Inst, CSIR, Div Med & Proc Chem, Lucknow 226031, Uttar Pradesh, India

[2] Cent Drug Res Inst, CSIR, Div Fermentat Technol, Med Mycol Lab, Lucknow 226031, Uttar Pradesh, India

来源：

ARKIVOC | 2014年

关键词：

THF alkynes; THF azides; C-nucleosides; 'click' chemistry; 1,2,3-triazoles; ANOMERIC CONFIGURATION; ANHYDRO-OSAZONES; CARBOCYCLIC NUCLEOSIDES; RIBAVIRIN; AZIDE; PHENYLOSAZONES;

D O I：

10.3998/ark.5550190.p008.374

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The construction of a novel series of enantiopure tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues utilizing click reaction of sugar derived tetrahydrofuranyl alkynes with various 'in house' synthesized sugar derived tetrahydrofuranyl azides and an adamantyl azide is described. The biological significance of the synthesized C-nucleosides was highlighted by evaluating them in vitro for anti-bacterial and anti-fungal activity, wherein a number of compounds were found to show excellent anti-bacterial activity and moderate anti-fungal activity.

引用

页码：170 / 182

页数：13

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