GD2-TARGETING CAR-NK CELLS ENHANCED BY TRANSGENIC GITRL EXPRESSION ARE AN EFFECTIVE FOR GLIOBLASTOMA AND MELANOMA

被引:0
|
作者
Tirapelle, M. C. [1 ,2 ]
Schmidt, D. D. [1 ,2 ]
Ebrahimabadi, S. [1 ,2 ]
Covas, D. [3 ]
Picanco-Castro, V. [4 ]
机构
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, Brazil
[2] Hemoctr Ribeirao Preto, Ribeirao Preto, Brazil
[3] Fundacao Hemoctr Ribeirao Preto, Ribeirao Preto, Brazil
[4] Blood Ctr Ribeirao Preto, Ribeirao Preto, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
NK cells; GD2; solid tumor;
D O I
暂无
中图分类号
Q813 [细胞工程];
学科分类号
摘要
1010
引用
收藏
页码:S199 / S199
页数:1
相关论文
共 30 条
  • [21] Dual Targeting of Glioblastoma Cells with Bispecific Killer Cell Engagers Directed to EGFR and ErbB2 (HER2) Facilitates Effective Elimination by NKG2D-CAR-Engineered NK Cells
    Kiefer, Anne
    Pruefer, Maren
    Roeder, Jasmin
    Serrahima, Jordi Pfeifer
    Bodden, Malena
    Kuehnel, Ines
    Oberoi, Pranav
    Wels, Winfried S.
    CELLS, 2024, 13 (03)
  • [22] Targeting HER2-Positive Solid Tumors with CAR NK Cells: CD44 Expression Is a Critical Modulator of HER2-Specific CAR NK Cell Efficacy
    Gergely, Bence
    Vereb, Mark A.
    Rebenku, Istvan
    Vereb, Gyorgy
    Szoor, Arpad
    CANCERS, 2025, 17 (05)
  • [23] DUAL TARGETING OF PD-L1 AND ERBB2 BY CAR-NK CELLS ENABLES SPECIFIC ELIMINATION OF SOLID TUMOR CELLS AND OVERCOMES IMMUNE ESCAPE VIA ANTIGEN LOSS
    Eitler, J.
    Freudenberg, K.
    Ben-Horin, I.
    Montero, P.
    Rackwitz, W.
    Wels, W.
    Tonn, T.
    HUMAN GENE THERAPY, 2023, 34 (21-22) : A15 - A16
  • [24] DUAL TARGETING OF CAR-NK CELLS TO PD-L1 AND HER2 FACILITATES SPECIFIC ELIMINATION OF CANCER CELLS OF SOLID TUMOR ORIGIN AND OVERCOMES IMMUNE ESCAPE BY ANTIGEN LOSS
    Eitler, J.
    Freudenberg, K.
    Montero, P. O.
    Rackwitz, W.
    Wels, W. S.
    Tonn, T.
    CYTOTHERAPY, 2023, 25 (06) : S221 - S222
  • [25] DUAL TARGETING OF CAR-NK CELLS TO PD-L1 AND HER2 FACILITATES SPECIFIC ELIMINATION OF CANCER CELLS OF SOLID TUMOR ORIGIN AND OVERCOMES IMMUNE ESCAPE BY ANTIGEN LOSS
    Eitler, J.
    Freudenberg, K.
    Montero, P.
    Wels, W.
    Tonn, T.
    CYTOTHERAPY, 2022, 24 (05) : S127 - S128
  • [26] A NOVEL LOCAL TREATMENT APPROACH? TARGETED IMMUNOTHERAPY OF GLIOBLASTOMA VIA AAVMEDIATED GENE TRANSFER OF CHECKPOINT INHIBITORS THROUGH LOCALLY ADMINISTERED HER2-AAVS IN COMBINATION WITH CAR-NK CELLS
    Strecker, M. I.
    Strassheimer, F.
    Reul, J.
    Harter, P. N.
    Tonn, T.
    Steinbach, J. P.
    Wels, W. S.
    Buchholz, C. J.
    Burger, M. C.
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A47 - A47
  • [27] DUAL TARGETING OF CAR-NK CELLS TO PD-L1 AND ERBB2 FACILITATES SPECIFIC ELIMINATION OF CANCER CELLS OF SOLID TUMOR ORIGIN AND OVERCOMES IMMUNE ESCAPE BY ANTIGEN LOSS
    Eitler, Jiri
    Freudenberg, Kristin
    Montero, Paola Ortiz
    Rackwitz, Wiebke
    Wels, Winfried
    Tonn, Torsten
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A230 - A230
  • [28] Tandem chimeric antigen receptor (CAR) T cells targeting EGFRvIII and IL-13Rα2 are effective against heterogeneous glioblastoma
    Schmidts, Andrea
    Srivastava, Ambike A.
    Ramapriyan, Rishab
    Bailey, Stefanie R.
    Bouffard, Amanda A.
    Cahill, Daniel P.
    Carter, Bob S.
    Curry, William T.
    Dunn, Gavin P.
    Frigault, Matthew J.
    Gerstner, Elizabeth R.
    Ghannam, Jack Y.
    Kann, Michael C.
    Larson, Rebecca C.
    Leick, Mark B.
    Nahed, Brian, V
    Richardson, Leland G.
    Scarfo, Irene
    Sun, Jing
    Wakimoto, Hiroaki
    Maus, Marcela, V
    Choi, Bryan D.
    NEURO-ONCOLOGY ADVANCES, 2023, 5 (01)
  • [29] CRISPR/CAS9 KNOCKOUT OF IMMUNE CHECKPOINT RECEPTOR NKG2A IMPROVES THE ANTI-LEUKEMIC EFFICACY OF PRIMARY CD33-TARGETING CAR-NK CELLS
    Albinger, Nawid
    Bexte, Tobias
    Al-Ajami, Ahmad
    Wendel, Philipp
    Buchinger, Leon
    Gessner, Alec
    Sarchen, Vinzenz
    Alzubi, Jamal
    Mertlitz, Sarah
    Penack, Olaf
    Bhayadia, Raj
    Heckl, Dirk
    Klusmann, Jan-Henning
    Vogler, Meike
    Moeker, Nina
    Cathomen, Toni
    Rieger, Michael A.
    Imkeller, Katharina
    Ullrich, Evelyn
    BONE MARROW TRANSPLANTATION, 2023, 58 (SUPP1) : 46 - 47
  • [30] "Dual Targeting" of CAR-NK Cells against PD-L1 and HER2 enables the specific Elimination of solid Tumors and overcomes "immune escape" through Antigen Loss
    Eitler, J.
    Freudenberg, K.
    Montero, P. Ortiz
    Bornhauser, M.
    Wels, W. S.
    Tonn, T.
    ONCOLOGY RESEARCH AND TREATMENT, 2022, 45 (SUPPL 2) : 124 - 124