Triterpenes from antler-shaped fruiting body of Ganoderma lucidum and their hepatoprotective activities

被引：3
|
作者：
Shao, Hongjie [1 ]
Li, Ye [2 ]
Wu, Changhui [2 ]
Chen, Ruoyun [1 ]
Kang, Jie [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing Key Lab Polymorph Drugs, 1 Xiannongtan St, Beijing 100050, Peoples R China
[2] Fujian Xianzhilou Biol Sci & Technol Co Ltd, 6 Chuangxin Rd,Hightech Zone, Fuzhou 350108, Peoples R China
来源：
PHYTOCHEMISTRY | 2024年 / 224卷
关键词：
Ganoderma lucidum (Leyss. ex Fr.) Karst; Polyporaceae; Triterpenes; Hepatoprotection; MOMORDICA-CHARANTIA; TOXICITY;
D O I：
10.1016/j.phytochem.2024.114148
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Seven previously undescribed triterpenes (1-7), as well as one triterpene (8) previously described as a synthetic product, were isolated from the antler-shaped fruiting body of Ganoderma lucidum. Their structures were established based on comprehensive spectroscopy analysis. At a concentration of 10 mu M, (24E)-3-oxo-15 alpha-acetoxy-lanosta-7,9(11),24-trien-26-al (3) and (24R,25S)-3-oxo-lanosta-7,9(11)-dien-25-ethoxyl-24,26-diol (5) provided significant protection against acetaminophen-induced necrosis in human HepG2 liver cancer cells, and the cell survival rates were 69.7 and 76.1% respectively, similar to that of the positive control (glutathione, 72.1%). Based on the present results, these compounds could be potential hepatoprotective agents.
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页数：10
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