Inflammatory markers, somatic complaints, use of medication and health care in 11-year-old children at familial high risk of schizophrenia or bipolar disorder compared with population-based controls. The Danish High Risk and Resilience Study - via 11

被引：0

作者：

Sondergaard, Anne ^{[1
,2
]}

Gregersen, Maja ^{[1
,2
,3
]}

Wilms, Martin ^{[1
,2
]}

Brandt, Julie Marie ^{[1
,2
]}

Hjorthoj, Carsten ^{[1
,2
,4
]}

Ohland, Jessica ^{[1
]}

Rohd, Sinnika Birkehoj ^{[1
,2
]}

Hemager, Nicoline ^{[1
,2
,5
]}

Andreassen, Anna Krogh ^{[2
,6
]}

Knudsen, Christina Bruun ^{[2
,6
]}

Veddum, Lotte ^{[2
,6
]}

Krantz, Mette Falkenberg ^{[2
,3
]}

Greve, Aja ^{[2
,6
,7
]}

Bliksted, Vibeke ^{[7
]}

Mors, Ole ^{[2
,6
,7
]}

Lykkegaard, Kasper ^{[8
]}

Krustrup, Peter ^{[9
]}

Thorup, Anne E. ^{[1
,2
,3
,10
]}

Nordentoft, Merete ^{[1
,2
,10
]}

机构：

[1] Copenhagen Univ Hosp, Mental Hlth Ctr Copenhagen, Mental Hlth Serv, Copenhagen, Capital Region, Denmark

[2] Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark

[3] Copenhagen Univ Hosp, Child & Adolescent Mental Hlth Ctr, Mental Hlth Serv CPH, Copenhagen, Denmark

[4] Univ Copenhagen, Dept Publ Hlth, Sect Epidemiol, Copenhagen, Denmark

[5] Univ Copenhagen, Dept Psychol, Copenhagen, Denmark

[6] Aarhus Univ Hosp, Psychosis Res Unit, Aarhus, Denmark

[7] Univ Southern, Dept Clin Res, Res Unit Psychiat Odense, Odense, Denmark

[8] SENS Innovat APS, Copenhagen, Denmark

[9] Univ Southern Denmark, Dept Sports Sci & Clin Biomech, Odense, Denmark

[10] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

来源：

NORDIC JOURNAL OF PSYCHIATRY | 2024年 / 78卷 / 06期

关键词：

Children at familial high risk of schizophrenia or bipolar disorder; inflammatory markers; somatic complaints; medication; health care use; C-REACTIVE PROTEIN; MAJOR DEPRESSIVE DISORDER; DIABETES-MELLITUS; PHYSICAL-ACTIVITY; MENTAL-ILLNESS; MORTALITY; METAANALYSIS; ASSOCIATION; ADOLESCENTS; PSYCHOPATHOLOGY;

D O I：

10.1080/08039488.2024.2369145

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Purpose: Patients with schizophrenia or bipolar disorder are at increased risk of somatic illnesses and have more somatic complaints compared with the general population. Schizophrenia and bipolar disorder are highly heritable. Already during childhood, children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BD) are at increased risk of psychiatric disorders and cognitive and social impairments. Knowledge about physical conditions is sparse.Materials and methods: Through blood tests (n = 293), interviews, and questionnaires, we assessed inflammatory markers, somatic complaints, medication - and health care use in 11-year-old children at FHR-SZ, FHR-BD, and population-based controls (PBC).Results: Children at FHR-SZ had higher concentrations of leucocytes (mean 6.41, SD 0.73) compared with PBC (mean 5.78, SD 0.27, p = 0.005) and of neutrophilocytes (FHR-SZ: mean 3.11, SD 1.32, PBC: mean 2.70, SD 0.96, p = 0.024). Compared with PBC (26.6%), more children at FHR-SZ (40.5%, p = 0.007) reported somatic complaints. So did caregivers and teachers to children at FHR-BD. Somatic complaints, higher concentrations of leucocytes, and neutrophilocytes were associated with lower levels of physical activity. Children at FHR-BD with psychiatric disorders reported more somatic complaints compared with those without.Conclusion: Children at FHR-SZ had higher concentrations of leucocytes and neutrophilocytes than PBC. Children at FHR-SZ or FHR-BP displayed more somatic complaints than controls. Our study highlights rarely explored disadvantage of being born to parents with schizophrenia or bipolar disorder. To enhance understanding of how physical conditions in childhood may interplay with later transition to mental disorders in children at FHR-SZ and FHR-BD, further research is needed.

引用

页码：507 / 517

页数：11

共 50 条

[21] Pubertal timing, sex hormone levels, and associations between early life adversity and accelerated development amongst 11-year-old children of parents with schizophrenia or bipolar disorder and controls: The Danish high risk and Resilience study via 11
Krantz, Mette Falkenberg
Frederiksen, Hanne
Hjorth, Carsten
Ondergaard, Anne S.
Brandt, Julie Marie
Rohd, Sinnika Birkehoj
Veddum, Lotte
Steffensen, Nanna Lawaetz
Knudsen, Christina Bruun
Andreasen, Anna Krogh
Hemager, Nicoline
Burton, Birgitte Klee
Gregersen, Maja
Greve, Aja Neergaard
Ohland, Jessica
Bliksted, Vibeke
Mors, Ole
Thorup, Anne A. E.
Juul, Anders
Nordentoft, Merete
COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY, 2023, 16
[22] Jumping to Conclusions and Its Associations With Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder-The Danish High Risk and Resilience Study, VIA 11
Gregersen, Maja
Rohd, Sinnika Birkehoj
Jepsen, Jens Richardt Mollegaard
Brandt, Julie Marie
Sondergaard, Anne
Hjorthoj, Carsten
Knudsen, Christina Bruun
Andreassen, Anna Krogh
Veddum, Lotte
Ohland, Jessica
Wilms, Martin
Krantz, Mette Falkenberg
Burton, Birgitte Klee
Greve, Aja
Bliksted, Vibeke
Mors, Ole
Clemmensen, Lars
Nordentoft, Merete
Thorup, Anne Amalie Elgaard
Hemager, Nicoline
SCHIZOPHRENIA BULLETIN, 2022, 48 (06) : 1363 - 1372
[23] Working memory heterogeneity from age 7 to 11 in children at familial high risk of schizophrenia or bipolar disorder- The Danish High Risk and Resilience Study
Andreassen, Anna Krogh
Lambek, Rikke
Hemager, Nicoline
Knudsen, Christina Bruun
Veddum, Lotte
Carlsen, Anders Helles
Bundgaard, Anette Faurskov
Sondergaard, Anne
Brandt, Julie Marie
Gregersen, Maja
Krantz, Mette Falkenberg
Burton, Birgitte Klee
Jepsen, Jens Richardt Mollegaard
Thorup, Anne Amalie Elgaard
Nordentoft, Merete
Mors, Ole
Bliksted, Vibeke Fuglsang
Greve, Aja
JOURNAL OF AFFECTIVE DISORDERS, 2023, 332 : 318 - 326
[24] Quality of life and self-esteem in 7-year-old children with familial high risk of schizophrenia or bipolar disorder: the Danish High Risk and Resilience Study-VIA 7-a population-based cohort study
Ellersgaard, Ditte
Gregersen, Maja
Ranning, Anne
Haspang, Thilde M.
Christiani, Camilla
Hemager, Nicoline
Burton, Birgitte Klee
Spang, Katrine Soeborg
Sondergaard, Anne
Greve, Aja
Gantriis, Ditte
Jepsen, Jens R. M.
Mors, Ole
Plessen, Kerstin J.
Nordentoft, Merete
Thorup, Anne A. E.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2020, 29 (06) : 849 - 860
[25] The Strengths and Difficulties Questionnaire Is of Clinical Significance Regarding Emotional and Behavioral Problems in 7-Year-Old Children With Familial Risk of Schizophrenia or Bipolar Disorder and Population-Based Controls the Danish High Risk and Resilience Study-VIA 7; A Population-Based Cohort Study
Spang, Katrine Soborg
Thorup, Anne A. E.
Ellersgaard, Ditte
Hemager, Nicoline
Christiani, Camilla
Burton, Birgitte Klee
Gantriis, Ditte
Greve, Aja
Gregersen, Maja
Mors, Ole
Nordentoft, Merete
Jepsen, Jens Richardt Mollegaard
Obel, Carsten
Plessen, Kerstin J.
FRONTIERS IN PSYCHIATRY, 2022, 13
[26] Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study
Christiani, Camilla Jerlang
Jepsen, Jens R. M.
Thorup, Anne
Hemager, Nicoline
Ellersgaard, Ditte
Spang, Katrine S.
Burton, Birgitte K.
Gregersen, Maja
Sondergaard, Anne
Greve, Aja N.
Gantriis, Ditte L.
Poulsen, Gry
Uddin, Md Jamal
Seidman, Larry J.
Mors, Ole
Plessen, Kerstin J.
Nordentoft, Merete
SCHIZOPHRENIA BULLETIN, 2019, 45 (06) : 1218 - 1230
[27] Attachment representations in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: Associations with mental disorders and daily functioning The Danish High Risk and Resilience Study, VIA 7-A population-based cohort study
Gregersen, Maja
Ellersgaard, Ditte
Sondergaard, Anne
Christiani, Camilla
Hemager, Nicoline
Spang, Katrine Soborg
Burton, Birgitte Klee
Uddin, Md Jamal
Ohland, Jessica
Gantriis, Ditte
Greve, Aja
Hjorthoj, Carsten
Mors, Ole
Plessen, Kerstin Jessica
Nordentoft, Merete
Clemmensen, Lars
Jepsen, Jens Richardt Mollegaard
Thorup, Anne Amalie Elgaard
SCANDINAVIAN JOURNAL OF PSYCHOLOGY, 2023, 64 (06) : 776 - 783
[28] The development in rating-based executive functions in children at familial high risk of schizophrenia or bipolar disorder from age 7 to age 11: the Danish high risk and resilience study
Andreassen, Anna Krogh
Lambek, Rikke
Greve, Aja
Hemager, Nicoline
Knudsen, Christina Bruun
Veddum, Lotte
Birk, Merete
Sondergaard, Anne
Brandt, Julie Marie
Gregersen, Maja
Falkenberg-Krantz, Mette
Spang, Katrine Soborg
Ohland, Jessica
Burton, Birgitte Klee
Jepsen, Jens Richardt Mollegaard
Thorup, Anne Amalie Elgaard
Nordentoft, Merete
Mors, Ole
Bliksted, Vibeke Fuglsang
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2024, 33 (02) : 549 - 560
[29] The development in rating-based executive functions in children at familial high risk of schizophrenia or bipolar disorder from age 7 to age 11: the Danish high risk and resilience study
Anna Krogh Andreassen
Rikke Lambek
Aja Greve
Nicoline Hemager
Christina Bruun Knudsen
Lotte Veddum
Merete Birk
Anne Søndergaard
Julie Marie Brandt
Maja Gregersen
Mette Falkenberg-Krantz
Katrine Søborg Spang
Jessica Ohland
Birgitte Klee Burton
Jens Richardt Møllegaard Jepsen
Anne Amalie Elgaard Thorup
Merete Nordentoft
Ole Mors
Vibeke Fuglsang Bliksted
European Child & Adolescent Psychiatry, 2024, 33 : 549 - 560
[30] Quality of Life and Self-esteem in 7-year-old Children with Familial High Risk of Schizophrenia or Bipolar Disorder - Correlations with Psychopathology and Level of Functioning in: The Danish High Risk and Resilience Study-VIA7; A Population-based Cohort Study
Ellersgaard, Ditte
Gregersen, Maja
Jepsen, Jens R. M.
Ranning, Anne
Hemager, Nicoline
Christiani, Camilla
Mors, Ole
Plessen, Kerstin J.
Thorup, Anne A. E.
Nordentoft, Merete
EARLY INTERVENTION IN PSYCHIATRY, 2018, 12 : 93 - 93

← 1 2 3 4 5 →