Efficacy of Non-Surgical Periodontal Therapy with Adjunctive Methylene Blue and Toluidine Blue O Mediated Photodynamic in Treatment of Periodontitis: A Randomized Clinical Trial

被引:1
|
作者
Najm, Kashan Kamal [1 ]
Gul, Sarhang Sarwat [1 ,2 ]
Abdulkareem, Ali Abbas [3 ]
机构
[1] Univ Sulaimani, Coll Dent, Dept Periodont, Sulaymaniyah 46001, Iraq
[2] Sulaimani Polytech Univ, Coll Hlth & Med Technol, Med Lab Dept, Sulaymaniyah 46001, Iraq
[3] Univ Baghdad, Coll Dent, Dept Periodont, Baghdad 10011, Iraq
关键词
periodontitis; periodontal therapy; photodynamic therapy; methylene blue; toluidine blue O; GINGIVAL CREVICULAR FLUID; PATHOGENS; BIOFILM; DISEASE; LASER;
D O I
10.3390/clinpract14030076
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: This study aimed to examine the efficacy of methylene blue (MB) and toluidine blue O (TBO) photodynamic therapy (PDT) as adjuncts to root surface debridement (RSD). Methods: This split-mouth, randomized, controlled clinical trial included eighteen patients, and a total of 332 sites (control = 102, MB = 124 and TBO = 106) were examined. Two sessions of PDT were completed at baseline and two weeks after RSD. Clinical parameters of bleeding on probing (BOP), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL) were measured pre- and post-treatment. Results: PPD and BOP reductions in sites treated by RSD with adjunctive photosensitizers (MB and TBO) were significantly higher than in control sites. RSD with MB showed higher efficacy in improving moderately deep pockets (OR 3.350), while adjunctive TBO showed better results in treating deeper pockets (OR 4.643). Conclusions: Results suggested that adjunctive use of MB and TBO to RSD could significantly improve periodontal pocket closure and reduce signs of inflammation. In addition, TBO seems to be more efficient in treating deep periodontal pockets than MB, which is more effective in resolving shallower pockets.
引用
收藏
页码:954 / 964
页数:11
相关论文
共 50 条
  • [41] Successful treatment ofPityriasis Versicolorby photodynamic therapy mediated by methylene blue
    Alberdi, Enrique
    Gomez, Clara
    PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 2020, 36 (04) : 308 - 312
  • [42] Methylene Blue-mediated Photodynamic Therapy for the Treatment of Oral Leukoplakia
    Bhandari, Akanksha
    Budakoti, Akansha
    Chaudhary, Manjari
    JOURNAL OF THE SCIENTIFIC SOCIETY, 2023, 50 (03) : 394 - 398
  • [43] TRANSFEROSOMAL METHYLENE BLUE MEDIATED PHOTODYNAMIC THERAPY FOR TREATMENT OF PLANTAR WARTS
    Fadel, Maha
    Kassab, Kawser
    Samy, Nevien
    Yassin, Ghada
    LASERS IN SURGERY AND MEDICINE, 2015, 47 (04) : 381 - 381
  • [44] Efficacy of Local Drug Delivery of 0.5% Clarithromycin Gel as an Adjunct to Non-Surgical Periodontal Therapy in the Treatment of Current Smokers With Chronic Periodontitis: A Randomized Controlled Clinical Trial
    Agarwal, Esha
    Pradeep, A. R.
    Bajaj, Pavan
    Naik, Savitha B.
    JOURNAL OF PERIODONTOLOGY, 2012, 83 (09) : 1155 - 1163
  • [45] Antimicrobial photodynamic therapy in treatment of aggressive periodontitis (stage III, grade C periodontitis): A comparison between photodynamic therapy and antibiotic therapy as an adjunct to non-surgical periodontal treatment
    Skaleric, Eva
    Petelin, Milan
    Gas, Boris
    PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2023, 41
  • [46] Reduction of gingival inflammation after 3 sessions of antimicrobial photodynamic therapy in generalized periodontitis non-surgical treatment: a randomized controlled clinical trial
    Areas e Souza A.
    da Silva Tavares K.R.
    Vidal P.M.
    Zuza E.C.
    de Oliveira Barceleiro M.
    da Costa Fontes K.B.F.
    Lasers in Dental Science, 2021, 5 (2) : 99 - 105
  • [47] Non-Surgical Periodontal Therapy with Adjunctive Amoxicillin/Metronidazole or Metronidazole When No Aggregatibacter actinomycetemcomitans Is Detected-A Randomized Clinical Trial
    Jentsch, Holger F. R.
    Dietrich, Martin
    Eick, Sigrun
    ANTIBIOTICS-BASEL, 2020, 9 (10): : 1 - 5
  • [48] Professional tooth cleaning prior non-surgical periodontal therapy: A randomized clinical trial
    Jentsch, Holger F. R.
    Heusinger, Thea
    Weickert, Anne
    Eick, Sigrun
    JOURNAL OF PERIODONTOLOGY, 2020, 91 (02) : 174 - 182
  • [49] Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: a randomized, controlled clinical trial
    Isola, Gaetano
    Polizzi, Alessandro
    Iorio-Siciliano, Vincenzo
    Alibrandi, Angela
    Ramaglia, Luca
    Leonardi, Rosalia
    CLINICAL ORAL INVESTIGATIONS, 2021, 25 (03) : 1035 - 1045
  • [50] Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: a randomized, controlled clinical trial
    Gaetano Isola
    Alessandro Polizzi
    Vincenzo Iorio-Siciliano
    Angela Alibrandi
    Luca Ramaglia
    Rosalia Leonardi
    Clinical Oral Investigations, 2021, 25 : 1035 - 1045