Optimization of boronic ester-based amphiphilic copolymers for ROS-responsive drug delivery

被引：1
|
作者：
Gao, Yuhan [1 ]
Yang, Ruhui [2 ,3 ]
Shou, Zeyu [4 ]
Zan, Xingjie [2 ,3 ,5 ]
Tang, Sicheng [2 ,3 ,5 ]
机构：
[1] Wenzhou Med Univ, Sch Pharm, Wenzhou 325035, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Sch Ophthalmol, Wenzhou 325035, Zhejiang, Peoples R China
[3] Wenzhou Med Univ, Optometry Eye Hosp, Sch Biomed Engn, Wenzhou 325035, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Affiliated Hosp 1, Dept Anesthesia, Wenzhou 325000, Peoples R China
[5] Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou Key Lab Perioperat Med, Wenzhou 325001, Zhejiang, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 52期
关键词：
Compendex;
D O I：
10.1039/d4cc01836b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This study introduces boronic ester-based ROS-responsive amphiphilic copolymers for antioxidant drug delivery. Tuning the hydrophobic/hydrophilic balance optimized the size, curcumin encapsulation, ROS-triggered release, cellular uptake, and intracellular ROS scavenging. The lead P1b formulation self-assembled into stable 10 nm micelles enabling rapid ROS-triggered curcumin release and preferential cellular internalization. P1b eliminated over 90% of pathogenic intracellular ROS within 10 minutes, demonstrating a rapid antioxidant therapy. This study introduces the optimization of boronic ester-based ROS-responsive amphiphilic copolymers for antioxidant drug delivery.
引用
收藏
页码：6683 / 6686
页数：4
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