Autophagy mediated targeting degradation, a promising strategy in drug development

被引:3
|
作者
Zhang, Jiantao [1 ]
Pan, Xiangyi [1 ]
Ji, Wenshu [1 ]
Zhou, Jinming [1 ]
机构
[1] Zhejiang Normal Univ, Dept Chem, Key Lab Minist Educ Adv Catalysis Mat, 688 Yingbin Rd, Jinhua 321004, Peoples R China
关键词
Autophagy; Protein degradation; ATTEC; AUTAC; AUTOTAC; PROTEIN-DEGRADATION; UBIQUITIN; SYSTEM; DOMAIN; CLEARANCE; DISCOVERY; CHIMERAS; PATHWAY; DISEASE; MTORC1;
D O I
10.1016/j.bioorg.2024.107466
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Targeted protein degradation (TPD) technologies have become promising therapeutic approaches through degrading disease-causing proteins via the protein degradation system. Autophagy is a fundamental biological process with a high relationship to protein degradation, which belongs to one of two main protein degradation pathways, the autophagy-lysosomal system. Recently, various autophagy-based TPD techniques ATTECs, AUTACs, and AUTOTACs, etc, have also been gradually developed, and they have achieved efficient degradation potency for the targeted protein, expanding the potential of degradation for large-size proteins or protein aggregates. Herein, we introduce the machinery of autophagy and its relation to protein degradation, and multiple methods for using autophagy to specifically degrade target proteins.
引用
收藏
页数:10
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