Synthesis of imidazo[1,2-a]pyridines a ]pyridines via cobalt/iodine-catalyzed Ortoleva-King type approach

被引：0

作者：

Saranya, Padinjare Veetil ^{[1
]}

Philip, Rose Mary ^{[1
]}

Anilkumar, Gopinathan ^{[1
,2
]}

机构：

[1] Mahatma Gandhi Univ, Sch Chem Sci, P D Hills P O, Kottayam 686560, Kerala, India

[2] Mahatma Gandhi Univ, Inst Integrated Programs & Res Basic Sci IIRBS, P D Hills P O, Kottayam 686560, Kerala, India

来源：

TETRAHEDRON LETTERS | 2024年 / 146卷

关键词：

Cobalt; Iodine; Ortoleva-King type; Zolimidine; Imidazo [1,2-a]pyridine; C-H FUNCTIONALIZATION; ACCESS; 2-AMINOPYRIDINES; PYRIDINES;

D O I：

10.1016/j.tetlet.2024.155188

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ortoleva-King type reaction of 2-aminopyridines with easily available aromatic ketones by dual catalytic system of cobalt and iodine in chlorobenzene was proposed. The reaction made use of the in situ formation of alpha-halo ketones from aromatic ketones and molecular iodine. An array of functional groups were tolerated in this strategy to allow the synthesis of variously substituted imidazo[1,2-a]pyridines a ]pyridines in moderate to good yields. Furthermore, this procedure was effectively used for the synthesis of zolimidine, a medicine that is sold as an anti-ulcer agent.

引用

页数：4

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