Effect of anisodamine on regional cerebral blood flow in patients with dizziness: A randomized single-blind controlled trial

被引：0
|
作者：
Chen, Liang [1 ]
Lei, Bei [2 ]
Li, Zhenxin [3 ]
Jiang, Jinqi [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Emergency, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Nucl Med, Shanghai, Peoples R China
[3] Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai, Peoples R China
来源：
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2024年 / 23卷 / 05期
关键词：
Regional cerebral blood flow; 99m Tc-ethyl cysteinate dimer; Single-photonemission computed tomography; Anisodamine; Dizziness; ETHYL CYSTEINATE DIMER; BRAIN PERFUSION SPECT; DISEASE; DISORDERS; IBUDILAST; SYMPTOMS; ISCHEMIA;
D O I：
10.37360/blacpma.24.23.5.52
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
This study aimed to evaluate the effect of anisodamine on regional cerebral blood flow (rCBF) and associated dizziness. 150 patients with dizziness induced by low rCBF were divided randomly into groups A (n = 60; anisodamine), P (n = 60; alprostadil), and C (n = 30; normal saline). rCBF and dizziness severity were evaluated. After treatment, rCBF values increased both in groups A and P. The subjective symptom of dizziness improved in 55 (91.7%) patients with the DHI score decreasing from 65.9 +/- 5.4 to 23.1 +/- 7.4 in group A, and the symptom improved in 37 (61.7%) patients with the DHI score decreasing from 66.8 +/- 6.2 to 43.8 +/- 8.6 in group P. The difference in DHI score and rCBF values in group A was more significant than that in group P. Anisodamine could increase rCBF and alleviate symptoms of dizziness more effectively than alprostadil.
引用
收藏
页码：811 / 822
页数：12
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