Non-coding RNA therapeutics in the treatment of heart failure

被引：1
|
作者：
Paterek, Aleksandra [1 ]
Zaleska-Kociecka, Marta [2 ]
Surzykiewicz, Mateusz [1 ]
Wojdynska, Zuzanna [2 ]
Leszek, Przemyslaw [2 ]
Maczewski, Michal [1 ]
机构：
[1] Ctr Postgrad Med Educ, Dept Clin Physiol, Marymoncka 99-103, PL-01813 Warsaw, Poland
[2] Natl Inst Cardiol, Heart Failure & Transplantol Dept, Mech Circulatory Support & Transplant Dept, Alpejska 42, PL-04628 Warsaw, Poland
来源：
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY | 2024年 / 10卷 / 04期
关键词：
Non-coding RNA; Heart failure; Therapy; Heart failure with reduced ejection fraction; MicroRNA; ANTISENSE OLIGONUCLEOTIDES; TARGETED DELIVERY; ANIMAL-MODEL; DOUBLE-BLIND; MICRORNAS; REVEALS; ANGIOTENSINOGEN; INTERFERENCE; HYPERTROPHY; SUPPRESSION;
D O I：
10.1093/ehjcvp/pvae027
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Non-coding RNA (ncRNA) therapeutics can target either ncRNAs or conventional messenger RNA, offering both superior pharmacokinetics and selectivity to conventional therapies and addressing new, previously unexplored pathways. Although no ncRNA has yet been approved for the treatment of heart failure, in this review we present five most promising pathways and agents that either are in human clinical trials or offer great promise in the near future.
引用
收藏
页码：353 / 360
页数：8
相关论文
共 50 条
  • [21] Scientists on the Spot: non-coding RNAs and heart failure
    Antoniades, Charalambos
    Condorelli, Gianluigi
    CARDIOVASCULAR RESEARCH, 2019, 115 (14) : E164 - E165
  • [22] Change of Heart: the Epitranscriptome of Small Non-coding RNAs in Heart Failure
    Tamar Woudenberg
    Nyika D. Kruyt
    Paul H. A. Quax
    A. Yaël Nossent
    Current Heart Failure Reports, 2022, 19 : 255 - 266
  • [23] Long non-coding RNA-targeting therapeutics: discovery and development update
    Khorkova, Olga
    Stahl, Jack
    Joji, Aswathy
    Volmar, Claude-Henry
    Zeier, Zane
    Wahlestedt, Claes
    EXPERT OPINION ON DRUG DISCOVERY, 2023, 18 (09) : 1011 - 1029
  • [24] Change of Heart: the Epitranscriptome of Small Non-coding RNAs in Heart Failure
    Woudenberg, Tamar
    Kruyt, Nyika D.
    Quax, Paul H. A.
    Nossent, A. Yael
    CURRENT HEART FAILURE REPORTS, 2022, 19 (05) : 255 - 266
  • [25] Non-coding RNA therapeutics in cardiovascular diseases and risk factors: Systematic review
    Ardiana, Meity
    Fadila, Asiyah Nurul
    Zuhra, Zakirah
    Kusuma, Nabilla Merdika
    Rurus, Made Edgard Surya Erlangga
    Oceandy, Delvac
    NON-CODING RNA RESEARCH, 2023, 8 (04): : 487 - 506
  • [26] Small Non-Coding RNA Targets of Antidepressant Treatment
    Lopez, Juan Pablo
    NEUROPSYCHOPHARMACOLOGY, 2016, 41 : S10 - S11
  • [27] Non-Coding RNA in the Pathogenesis, Progression and Treatment of Hypertension
    Leimena, Christiana
    Qiu, Hongyu
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (04)
  • [28] Landscape of the long non-coding RNA transcriptome in human heart
    Jiang, Chunjie
    Ding, Na
    Li, Junyi
    Jin, Xiyun
    Li, Lili
    Pan, Tao
    Huo, Caiqin
    Li, Yongsheng
    Xu, Juan
    Li, Xia
    BRIEFINGS IN BIOINFORMATICS, 2019, 20 (05) : 1812 - 1825
  • [29] New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments
    Brichant, Geraldine
    Laraki, Ines
    Henry, Laurie
    Munaut, Carine
    Nisolle, Michelle
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (19)
  • [30] Non-coding RNA in cancer
    Yan, Huiwen
    Bu, Pengcheng
    NON-CODING GENOME, 2021, 65 (04): : 625 - 639
12345