Synthesis of Benzoxazinones via DIPEA-Promoted Condensation of Benzoxazoles with α-Keto Acids

被引：0
|
作者：
Yang, Zhiyong [1 ]
Yan, Jiaqi [1 ]
Guo, Jing [1 ]
Chen, Ping [1 ]
机构：
[1] Hunan Univ Arts & Sci, Furong Coll, Changde, Hunan Province, Peoples R China
来源：
CHEMISTRYSELECT | 2024年 / 9卷 / 30期
关键词：
3-Aryl-2H-Benzo[b][1,4]oxazin-2-ones; Benzoxazoles; alpha-Keto acids; DIPEA; Metal-free; DERIVATIVES; INHIBITORS; ARYLATION;
D O I：
10.1002/slct.202401876
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and environmental protocol for the synthesis of 3-aryl-2H-benzo[b][1,4]oxazin-2-ones under mild benign conditions has been developed. This facile one-pot approach to 3-aryl-2H-benzo[b][1,4]oxazin-2-ones from commercially available benzoxazoles and alpha-keto acids which only promoted by DIPEA. The protocol exhibits a wide range of applicability in terms of benzoxazoles and alpha-keto acids. Notably, the 2-aryl benzothiazoles can be produced under the similar reaction conditions.
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页数：4
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