Role of molecular biology in the management of pancreatic cancer

被引：0

作者：

Boileve, Alice ^{[1
]}

Smolenschi, Cristina ^{[1
]}

Lambert, Aurelien ^{[2
]}

Boige, Valerie ^{[1
]}

Tarabay, Anthony ^{[1
]}

Valery, Marine ^{[1
]}

Fuerea, Alina ^{[1
]}

Pudlarz, Thomas ^{[1
]}

Conroy, Thierry ^{[2
]}

Hollebecque, Antoine ^{[1
]}

Ducreux, Michel ^{[1
]}

机构：

[1] Gustave Roussy, Dept Med, 114 Rue Edouard Vaillant, F-94800 Villejuif, France

[2] Inst Cancerol Lorraine, Dept Med Oncol, F-54519 Nancy, France

来源：

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY | 2024年 / 16卷 / 07期

关键词：

Pancreatic cancer; Precision medicine; KRAS; Molecular profile; Targeted therapies; Liquid biopsy; POSITIVE SOLID TUMORS; OPEN-LABEL; PRECISION MEDICINE; METASTATIC CHOLANGIOCARCINOMA; GEMCITABINE SENSITIVITY; DUCTAL ADENOCARCINOMA; MUTATIONAL LANDSCAPE; PHASE; 1/2; MULTICENTER; LUNG;

D O I：

10.4251/wjgo.v16.i7.2902

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges in patient management due to a dismal prognosis, increasing incidence, and limited treatment options. In this regard, precision medicine, which personalizes treatments based on tumour molecular characteristics, has gained great interest. However, its widespread implementation is not fully endorsed in current recommendations. This review explores key molecular alterations in PDAC, while emphasizing differences between KRAS-mutated and KRAS-wild-type tumours. It assesses the practical application of precision medicine in clinical settings and outlines potential future directions with respect to PDAC. Actionable molecular targets are examined with the aim of enhancing our understanding of PDAC molecular biology. Insights from this analysis may contribute to a more refined and personalized approach to pancreatic cancer treatment, ultimately improving patient outcomes.

引用

页数：14

共 50 条

[21] The role of radiotherapy in management of pancreatic cancer
Wang, Fen
Kumar, Parvesh
JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2011, 2 (03) : 157 - 167
[22] Biology and molecular pathology in the management of breast cancer
Lopes, CS
10TH INTERNATIONAL MEETING OF GYNAECOLOGICAL ONCOLOGY, 1997, : 363 - 368
[23] Molecular biology, models, and histopathology of chronic pancreatitis and pancreatic cancer
Mihaljevic, A. L.
Esposito, I.
Friess, H.
Kleeff, J.
EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA, 2009, 41 (06): : 250 - 267
[24] Molecular Biology of Pancreatic Cancer: How Useful Is It in Clinical Practice?
Sakorafas, George H.
Smyrniotis, Vasileios
JOURNAL OF THE PANCREAS, 2012, 13 (04): : 332 - 337
[25] Molecular biology of pancreatic adenocarcinoma
Rueckert, F.
Aust, D.
Pilarsky, C.
Gruetzmann, R.
ONKOLOGE, 2010, 16 (06): : 5 - +
[26] Role of Endoscopic Ultrasound in the Management of Pancreatic Cancer
Musunuri, Balaji
Shetty, Shiran
INDIAN JOURNAL OF SURGICAL ONCOLOGY, 2024, 15 (SUPPL 2) : 269 - 274
[27] The role of PET/CT in the management of pancreatic cancer
Kommana, Harisha
Magram, Martin
Dilsizian, Vasken
JOURNAL OF NUCLEAR MEDICINE, 2009, 50
[28] Role of Neoadjuvant Therapy in Management of Pancreatic Cancer
Li, Jia
Saif, Muhammad Wasif
JOURNAL OF THE PANCREAS, 2014, 15 (04): : 354 - 357
[29] Role of radiation therapy in the management of pancreatic cancer
Huguet, F.
del Campo, E. Rivin
Antoni, D.
Vendrely, V.
Hammel, P.
CANCER RADIOTHERAPIE, 2018, 22 (6-7): : 552 - 557
[30] Role of radiation therapy in the management of pancreatic cancer
Goodman, Karyn A.
Hajj, Carla
JOURNAL OF SURGICAL ONCOLOGY, 2013, 107 (01) : 86 - 96

← 1 2 3 4 5 →