Role of molecular biology in the management of pancreatic cancer

被引：0

作者：

Boileve, Alice ^{[1
]}

Smolenschi, Cristina ^{[1
]}

Lambert, Aurelien ^{[2
]}

Boige, Valerie ^{[1
]}

Tarabay, Anthony ^{[1
]}

Valery, Marine ^{[1
]}

Fuerea, Alina ^{[1
]}

Pudlarz, Thomas ^{[1
]}

Conroy, Thierry ^{[2
]}

Hollebecque, Antoine ^{[1
]}

Ducreux, Michel ^{[1
]}

机构：

[1] Gustave Roussy, Dept Med, 114 Rue Edouard Vaillant, F-94800 Villejuif, France

[2] Inst Cancerol Lorraine, Dept Med Oncol, F-54519 Nancy, France

来源：

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY | 2024年 / 16卷 / 07期

关键词：

Pancreatic cancer; Precision medicine; KRAS; Molecular profile; Targeted therapies; Liquid biopsy; POSITIVE SOLID TUMORS; OPEN-LABEL; PRECISION MEDICINE; METASTATIC CHOLANGIOCARCINOMA; GEMCITABINE SENSITIVITY; DUCTAL ADENOCARCINOMA; MUTATIONAL LANDSCAPE; PHASE; 1/2; MULTICENTER; LUNG;

D O I：

10.4251/wjgo.v16.i7.2902

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges in patient management due to a dismal prognosis, increasing incidence, and limited treatment options. In this regard, precision medicine, which personalizes treatments based on tumour molecular characteristics, has gained great interest. However, its widespread implementation is not fully endorsed in current recommendations. This review explores key molecular alterations in PDAC, while emphasizing differences between KRAS-mutated and KRAS-wild-type tumours. It assesses the practical application of precision medicine in clinical settings and outlines potential future directions with respect to PDAC. Actionable molecular targets are examined with the aim of enhancing our understanding of PDAC molecular biology. Insights from this analysis may contribute to a more refined and personalized approach to pancreatic cancer treatment, ultimately improving patient outcomes.

引用

页数：14

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