Non-invasive detection of Aspergillosis in ventilated patients: Galactomannan analysis in exhaled breath

被引：0
|
作者：
Tang, XiaoHong [1 ]
Yang, Lei [2 ]
Zhang, Rong [3 ]
Fang, Hong [1 ]
Tang, Huan [4 ]
Xie, Qian [1 ]
Wang, HaiLian [5 ]
Chen, Lin [1 ]
Yang, Yang [1 ]
机构：
[1] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Pulm & Crit Care Med, 32,West 2nd Sect,1st Ring Rd, Chengdu 610072, Peoples R China
[2] Enyang Dist Peoples Hosp Bazhong City, Dept Pulm & Crit Care Med, Bazhong, Peoples R China
[3] Southwest Med Univ, Dept Pulm & Crit Care Med, Luzhou, Peoples R China
[4] North Sichuan Med Collage, Dept Intens Care Unit, Nanchong, Peoples R China
[5] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Clin Immunol Translat Med Key Lab Sichuan Prov, Chengdu, Peoples R China
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2024年 / 110卷 / 01期
关键词：
Bronchoalveolar lavage fluid; Diagnosis; Exhaled breath condensate; Galactomannan; Invasive pulmonary aspergillosis; Non; -invasive; BRONCHOALVEOLAR LAVAGE FLUID;
D O I：
10.1016/j.diagmicrobio.2024.116420
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
This study evaluates the non-invasive diagnosis of Invasive Aspergillosis Pneumonia (IPA) in mechanically ventilated patients by measuring galactomannan (GM) in exhaled breath condensate (EBC). Utilizing a rat model and a novel EBC collection device, we compared GM levels in bronchoalveolar lavage fluid (BALF) and EBC, supplemented by cytokine profiling. Analysis of 75 patients confirmed the device's efficacy, with EBC-GM and BALF-GM showing high diagnostic accuracy (AUC = 0.88). The threshold of 0.235 ng/ml for EBC-GM achieved 92.8 % sensitivity and 66.7 % specificity, with a strong correlation (r = 0.707, P < 0.001) with BALF-GM. This approach offers a safe, effective alternative to invasive diagnostics, enhancing precision with IL-6 and TNF-alpha measurements.
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页数：7
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