In vitro corrosion and cytocompatibility of Mg-Zn-Ca alloys coated with FHA

被引：1
|
作者：
Lan, Weiwei [1 ,2 ]
Li, Jun [1 ]
Lv, Zhenjun [1 ]
Liu, Shuang [1 ]
Liang, Ziwei [1 ,2 ]
Huang, Di [1 ,2 ]
Wei, Xiaochun [3 ]
Chen, Weiyi [1 ,2 ]
机构：
[1] Taiyuan Univ Technol, Coll Biomed Engn, Res Ctr Nanobiomat & Regenerat Med, Dept Biomed Engn, Taiyuan 030024, Peoples R China
[2] Shanxi Zheda Inst Adv Mat & Chem Engn, Taiyuan 030060, Shanxi, Peoples R China
[3] Shanxi Med Univ, Hosp 2, Dept Orthopaed, Taiyuan, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2024年 / 238卷
基金：
中国国家自然科学基金;
关键词：
Mg-Zn-Ca Alloys; Fluorohydroxyapatite; Electrodeposition; RESISTANCE; DEGRADATION;
D O I：
10.1016/j.colsurfb.2024.113880
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
In the field of orthopedics, it 's crucial to effectively slow down the degradation rate of Mg alloys. This study aims to improve the degradation behavior of Mg-Zn-Ca alloys by electrodepositing fluorohydroxyapatite (FHA). We investigated the microstructure and bond strength of the deposition, as well as degradation and cellular reactions. After 15 -30 days of degradation in Hanks solution, FHA deposited alloys showed enhanced stability and less pH change. The strong interfacial bond between FHA and the Mg-Zn-Ca substrate was verified through scratch tests (Critical loads: 10.73 +/- 0.014 N in Mg-Zn-0.5Ca alloys). Cellular studies demonstrated that FHAcoated alloys exhibited good cytocompatibility and promoted the growth of MC3T3-E1 cells. Further tests showed FHA -coated alloys owed improved early bone mineralization and osteogenic properties, especially in MgZn-0.5Ca. This research highlighted the potential of FHA -coated Mg-Zn-0.5Ca alloys in orthopedics applications.
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收藏
页数：9
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