The interplay between biochemical mediators and mechanotransduction in chondrocytes: Unravelling the differential responses in primary knee osteoarthritis

被引:13
|
作者
Segarra-Queralt, Maria [1 ]
Crump, Katherine [2 ,3 ]
Pascuet-Fontanet, Andreu [1 ]
Gantenbein, Benjamin [2 ,4 ]
Noailly, Jerome [1 ]
机构
[1] Univ Pompeu Fabra, BCN MedTech, C Merce 12, Barcelona 08002, Catalonia, Spain
[2] Univ Bern, Med Fac, Dept Biomed Res DBMR, Bone & Joint Program,Tissue Engn Orthopaed & Mecha, Murtenstr 35, CH-3008 Bern, Switzerland
[3] Univ Bern, Grad Sch Cellular & Biomed Sci GCB, Mittelstr 43, CH-3012 Bern, Switzerland
[4] Univ Bern, Dept Orthopaed Surg & Traumatol, Inselspital, Freiburgstr 18, CH-3010 Bern, Switzerland
基金
欧洲研究理事会;
关键词
Mechanotransduction; Knee; Osteoarthritis; Chondrocyte; Mechanoreceptor; Biochemical mediators; EXTRACELLULAR-MATRIX PROTEINS; HUMAN ARTICULAR CHONDROCYTES; PRESSURE-INDUCED STRAIN; GROWTH-FACTOR-I; PRIMARY CILIA; SIGNAL-TRANSDUCTION; ALPHA-5-BETA-1; INTEGRIN; BIOSYNTHETIC RESPONSE; INFLAMMATORY DISEASE; GENE-EXPRESSION;
D O I
10.1016/j.plrev.2024.02.003
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In primary or idiopathic osteoarthritis (OA), it is unclear which factors trigger the shift of articular chondrocyte activity from pro-anabolic to pro-catabolic. In fact, there is a controversy about the aetiology of primary OA, either mechanical or inflammatory. Chondrocytes are mechanosensitive cells, that integrate mechanical stimuli into cellular responses in a process known as mechanotransduction. Mechanotransduction occurs thanks to the activation of mechanosensors, a set of specialized proteins that convert physical cues into intracellular signalling cascades. Moderate levels of mechanical loads maintain normal tissue function and have anti-inflammatory effects. In contrast, mechanical over- or under-loading might lead to cartilage destruction and increased expression of pro-inflammatory cytokines. Simultaneously, mechanotransduction processes can regulate and be regulated by pro- and anti-inflammatory soluble mediators, both local (cells of the same joint, i.e., the chondrocytes themselves, infiltrating macrophages, fibroblasts or osteoclasts) and systemic (from other tissues, e.g., adipokines). Thus, the complex process of mechanotransduction might be altered in OA, so that cartilagepreserving chondrocytes adopt a different sensitivity to mechanical signals, and mechanic stimuli positively transduced in the healthy cartilage may become deleterious under OA conditions. This review aims to provide an overview of how the biochemical exposome of chondrocytes can alter important mechanotransduction processes in these cells. Four principal mechanosensors, i.e., integrins, Ca 2+ channels, primary cilium and Wnt signalling (canonical and non-canonical) were targeted. For each of these mechanosensors, a brief summary of the response to mechanical loads under healthy or OA conditions is followed by a concise overview of published works that focus on the further regulation of the mechanotransduction pathways by biochemical factors. In conclusion, this paper discusses and explores how biological mediators influence the differential behaviour of chondrocytes under mechanical loads in healthy and primary OA.
引用
收藏
页码:205 / 221
页数:17
相关论文
共 50 条
  • [41] The Relationship Between Primary Knee Osteoarthritis and Aortic Stiffness, Distensibility, and Valve Calcifications A Case-Control Study
    Karaali, Evren
    Ciloglu, Osman
    Yucel, Ceyhun
    Ekiz, Timur
    JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2022, 28 (01) : E9 - E12
  • [42] Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: a prospective cohort study
    Yuanyuan Wang
    Julie Anne Simpson
    Anita E Wluka
    Andrew J Teichtahl
    Dallas R English
    Graham G Giles
    Stephen Graves
    Flavia M Cicuttini
    Arthritis Research & Therapy, 11
  • [43] The association between radiographic severity and pre-operative function in patients undergoing primary knee replacement for osteoarthritis
    Dowsey, Michelle M.
    Dieppe, Paul
    Lohmander, Stefan
    Castle, David
    Liew, Danny
    Choong, Peter F. M.
    KNEE, 2012, 19 (06): : 860 - 865
  • [44] Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis
    Honsawek, Sittisak
    Yuktanandana, Pongsak
    Tanavalee, Aree
    Saetan, Natthaphon
    Anomasiri, Wilai
    Parkpian, Vinai
    INTERNATIONAL ORTHOPAEDICS, 2012, 36 (05) : 981 - 985
  • [45] Relationship between serum and synovial fluid CCL20 concentrations with disease severity in primary knee osteoarthritis
    Guan, Jian
    Li, Yao
    Ding, Luo-Bin
    Liu, Guang-Yuan
    Zheng, Xiao-Fei
    Xue, Wei
    Wang, Hua-Jun
    JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS, 2019, 19 (03) : 326 - 332
  • [46] A preliminary analysis of microRNA profiles in the subchondral bone between Kashin-Beck disease and primary knee osteoarthritis
    Zhao, Guang-Hui
    Yang, Lei
    Lammi, Mikko J.
    Guo, Xiong
    CLINICAL RHEUMATOLOGY, 2019, 38 (09) : 2637 - 2645
  • [47] Correlation between plasma and synovial fluid basic fibroblast growth factor with radiographic severity in primary knee osteoarthritis
    Sittisak Honsawek
    Pongsak Yuktanandana
    Aree Tanavalee
    Natthaphon Saetan
    Wilai Anomasiri
    Vinai Parkpian
    International Orthopaedics, 2012, 36 : 981 - 985
  • [48] Relationship between serum 25-hydroxy vitamin D levels, knee pain, radiological osteoarthritis, and the Western Ontario and McMaster Universities Osteoarthritis Index in patients with primary osteoarthritis
    Ahmed Lotfi A
    Rasha A. Abdel-Magied
    Rawhya R. El-Shereef
    Ahmed A. Saedii
    Ehab A. AbdelGawad
    Egyptian Rheumatology and Rehabilitation, 2014, 41 (2) : 66 - 70
  • [49] Differences in knee joint degeneration between primary hip osteoarthritis and hip osteoarthritis secondary to hip developmental dysplasia: A propensity score-based analysis
    Sato, Ryuichi
    Ando, Wataru
    Hamada, Hidetoshi
    Takao, Masaki
    Saito, Mitsuru
    Sugano, Nobuhiko
    MODERN RHEUMATOLOGY, 2021, 31 (06) : 1221 - 1227
  • [50] EPISTASIS BETWEEN TWO GENE VARIANTS OF LEPTIN AND VASCULAR ENDOTHELIAL GROWTH FACTOR GENES IN THE DEVELOPMENT OF PRIMARY KNEE OSTEOARTHRITIS
    Sosa-Arellano, Matvey
    Gonzalez-Huerta, Norma C.
    Morales-Hernandez, Eugenio
    Duarte-Salazar, Carolina
    Miranda-Duarte, Antonio
    REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION, 2022, 74 (02): : 81 - 89