How Do Cartilage Lubrication Mechanisms Fail in Osteoarthritis? A Comprehensive Review

被引:3
|
作者
Rajankunte Mahadeshwara, Manoj [1 ,2 ]
Al-Jawad, Maisoon [2 ]
Hall, Richard M. [3 ]
Pandit, Hemant [4 ]
El-Gendy, Reem [2 ,5 ]
Bryant, Michael [1 ,3 ]
机构
[1] Univ Leeds, Inst Funct Surfaces, Mech Engn, Leeds LS2 9JT, England
[2] Univ Leeds, Fac Dent, Dept Oral Biol, Leeds LS2 9JT, England
[3] Univ Birmingham, Coll Engn & Phys Sci, Sch Engn, Birmingham B15 2TT, England
[4] Univ Leeds, Chapel Allerton Hosp, Leeds Inst Rheumat & Musculoskeletal Med LIRMM, Leeds LS7 4SA, England
[5] Suez Canal Univ, Fac Dent, Dept Oral Pathol, Ismailia 3, Ismailia 8366004, Egypt
来源
BIOENGINEERING-BASEL | 2024年 / 11卷 / 06期
基金
英国工程与自然科学研究理事会;
关键词
tissue engineering; biotribology; cartilage lubrication; osteoarthritis treatment; intra-articular injections;
D O I
10.3390/bioengineering11060541
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Cartilage degeneration is a characteristic of osteoarthritis (OA), which is often observed in aging populations. This degeneration is due to the breakdown of articular cartilage (AC) mechanical and tribological properties primarily attributed to lubrication failure. Understanding the reasons behind these failures and identifying potential solutions could have significant economic and societal implications, ultimately enhancing quality of life. This review provides an overview of developments in the field of AC, focusing on its mechanical and tribological properties. The emphasis is on the role of lubrication in degraded AC, offering insights into its structure and function relationship. Further, it explores the fundamental connection between AC mechano-tribological properties and the advancement of its degradation and puts forth recommendations for strategies to boost its lubrication efficiency.
引用
收藏
页数:28
相关论文
共 50 条
  • [1] A Comprehensive Review of Stem Cells for Cartilage Regeneration in Osteoarthritis
    Kalamegam, Gauthaman
    Memic, Adnan
    Budd, Emma
    Abbas, Mohammed
    Mobasheri, Ali
    CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 2: APPROACHES FOR DIVERSE DISEASES AND CONDITIONS, 2018, 1089 : 23 - 36
  • [2] Biphasic and boundary lubrication mechanisms in artificial hydrogel cartilage: A review
    Murakami, Teruo
    Yarimitsu, Seido
    Nakashima, Kazuhiro
    Sakai, Nobuo
    Yamaguchi, Tetsuo
    Sawae, Yoshinori
    Suzuki, Atsushi
    PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, 2015, 229 (12) : 864 - 878
  • [3] LUBRICATION MECHANISMS AT THE SURFACE OF ARTICULAR CARTILAGE
    Butcher, A. L.
    Klein, J.
    OSTEOARTHRITIS AND CARTILAGE, 2020, 28 : S186 - S186
  • [4] Recent Advances in Understanding the Role of Cartilage Lubrication in Osteoarthritis
    Li, Yumei
    Yuan, Zhongrun
    Yang, Hui
    Zhong, Haijian
    Peng, Weijie
    Xie, Renjian
    MOLECULES, 2021, 26 (20):
  • [5] How Do Systems Fail?
    O'Halloran, Bryan
    Van Bossuyt, Douglas L.
    2020 ANNUAL RELIABILITY AND MAINTAINABILITY SYMPOSIUM (RAMS 2020), 2020,
  • [6] Molecular mechanisms of cartilage remodelling in osteoarthritis
    Bertrand, Jessica
    Cromme, Christoph
    Umlauf, Daniel
    Frank, Svetlana
    Pap, Thomas
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2010, 42 (10): : 1594 - 1601
  • [7] How do small quantities of cartilage sodium channels play a significant role in osteoarthritis?
    Kong, Xiaohong
    Liu, Chuan-Ju
    CLINICAL AND TRANSLATIONAL MEDICINE, 2024, 14 (03):
  • [8] Identification and Molecular Mechanisms Study of Genes Associated with Osteoarthritis: A Comprehensive Bioinformatic Study of Cartilage and Synovium
    Li, Shuai
    Wang, Xiaoquan
    Li, Jingxian
    Wei, Wuzeng
    Liu, Jun
    CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2022, 32 (02): : 25 - 38
  • [9] Boundary cartilage lubrication: review of current concepts
    Daniel, Matej
    WIENER MEDIZINISCHE WOCHENSCHRIFT, 2014, 164 (5-6) : 88 - 94
  • [10] Developmental Mechanisms in Articular Cartilage Degradation in Osteoarthritis
    Tchetina, Elena V.
    ARTHRITIS, 2011,